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RGS3 Monoclonal antibody, PBS Only

RGS3 Monoclonal Antibody for WB, ELISA

Host / Isotype

Mouse / IgG1

Reactivity

Human

Applications

WB, ELISA

Conjugate

Unconjugated

CloneNo.

1D6A3

Cat no : 66790-1-PBS

Synonyms

C2PA, FLJ20370, FLJ31516, FLJ90496, PDZ RGS3, RGP3, RGS3

Validation Data Gallery

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  • Western Blot (WB) analysis of Jurkat cells using RGS3 Monoclonal antibody (66790-1-Ig)

    WB analysis of Jurkat using 66790-1-Ig (same clone as 66790-1-PBS)

    Jurkat cells were subjected to SDS PAGE followed by western blot with 66790-1-Ig (RGS3 antibody) at dilution of 1:2000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 66790-1-PBS in a different storage buffer formulation.

  • Western Blot (WB) analysis of HEK-293 cells using RGS3 Monoclonal antibody (66790-1-Ig)

    WB analysis of HEK-293 using 66790-1-Ig (same clone as 66790-1-PBS)

    HEK-293 cells were subjected to SDS PAGE followed by western blot with 66790-1-Ig (RGS3 antibody) at dilution of 1:2000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 66790-1-PBS in a different storage buffer formulation.

Product Information

66790-1-PBS targets RGS3 in WB, ELISA applications and shows reactivity with Human samples.

Tested Reactivity Human
Host / Isotype Mouse / IgG1
Class Monoclonal
Type Antibody
Immunogen RGS3 fusion protein Ag3177
Full Name regulator of G-protein signaling 3
Calculated Molecular Weight 1198 aa, 132 kDa
Observed Molecular Weight 140 kDa
GenBank Accession NumberBC018072
Gene Symbol RGS3
Gene ID (NCBI) 5998
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purification
Storage Buffer PBS only
Storage ConditionsStore at -80°C.

Background Information

RGS3 belongs to a family of proteins which share the core regulator of G-protein signalling (RGS) domain and function as GTPase-activating proteins (GAPs) for the α subunit of heterotrimeric G-proteins. RGS3 has been reported to inhibit the Gai-and Gaq-mediated signaling pathways in the cardiovascular system, including those acting via the cardiovascular signaling molecules angiotensin II (Ang II), sphingosine 1-phosphate and endothelin-1. Alternative splicing and the use of alternative promoters results in multiple transcript variants encoding different isoforms. Long isoforms are largely cytosolic and plasma membrane-associated with a function in Wnt signaling and in the epithelial mesenchymal transition, while shorter N-terminally-truncated isoforms can be nuclear.