RANK/TNFRSF11A Polyclonal antibody

RANK/TNFRSF11A Polyclonal Antibody for WB, ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

WB, ELISA

Conjugate

Unconjugated

Cat no : 55293-1-AP

Synonyms

TNFRSF11A, TNR11, Receptor activator of NF-KB, Receptor activator of NF KB, RANK

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Validation Data Gallery

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  WB analysis using 55293-1-AP

  Various lysates were subjected to SDS PAGE followed by western blot with 55293-1-AP (RANK antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours.

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Tested Applications

• Positive WB detected in: MJ cells

Recommended dilution

• Western Blot (WB): WB : 1:500-1:1000

It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Sample-dependent, Check data in validation data gallery.

Product Information

55293-1-AP targets RANK/TNFRSF11A in WB, ELISA applications and shows reactivity with human samples.

• Tested Reactivity: human
• Host / Isotype: Rabbit / IgG
• Class: Polyclonal
• Type: Antibody
• Immunogen: Peptide
• Full Name: tumor necrosis factor receptor superfamily, member 11a, NFKB activator
• Calculated Molecular Weight: 66 kDa
• Observed Molecular Weight: 80-90 kDa
• GenBank Accession Number: NM_003839
• Gene Symbol: TNFRSF11A
• Gene ID (NCBI): 8792
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Antigen affinity purification
• Storage Buffer: PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
• Storage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20^oC storage. 20ul sizes contain 0.1% BSA.

Background Information

Tumor necrosis factor receptor superfamily member 11A (TNFRSF11A, also known as RANK, CD265, and ODFR) is the signaling receptor essential for osteoclast differentiation factor-mediated osteoclastogenesis and is involved in the regulation of interactions between T-cells and dendritic cells (PMID: 9878548). The RANK/RANKL/OPG system is a key regulator in bone resorption, and its dysregulation can lead to pathological bone loss (PMID: 37893470).