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RAMP2 Polyclonal antibody, PBS Only

RAMP2 Polyclonal Antibody for WB, IHC, Indirect ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse, rat

Applications

WB, IHC, Indirect ELISA

Conjugate

Unconjugated

Cat no : 13223-2-PBS

Synonyms

Validation Data Gallery

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  • Western Blot (WB) analysis of mouse brain tissue using RAMP2 Polyclonal antibody (13223-2-AP)

    WB analysis of mouse brain using 13223-2-AP (same clone as 13223-2-PBS)

    mouse brain tissue were subjected to SDS PAGE followed by western blot with 13223-2-AP (RAMP2 antibody) at dilution of 1:400 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 13223-2-PBS in a different storage buffer formulation.

  • Immunohistochemistry (IHC) staining of human breast cancer tissue using RAMP2 Polyclonal antibody (13223-2-AP)

    IHC staining of human breast cancer using 13223-2-AP (same clone as 13223-2-PBS)

    Immunohistochemical analysis of paraffin-embedded human breast cancer using 13223-2-AP (RAMP2 antibody) at dilution of 1:100 (under 10x lens). This data was developed using the same antibody clone with 13223-2-PBS in a different storage buffer formulation.

Product Information

13223-2-PBS targets RAMP2 in WB, IHC, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.

Tested Reactivity human, mouse, rat
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen RAMP2 fusion protein Ag4028
Full Name receptor (G protein-coupled) activity modifying protein 2
Calculated Molecular Weight 175 aa, 20 kDa
Observed Molecular Weight 20 kDa
GenBank Accession NumberBC027975
Gene Symbol RAMP2
Gene ID (NCBI) 10266
RRIDAB_2176337
Conjugate Unconjugated
Form Liquid
Purification MethodAntigen affinity purification
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.

Background Information

RAMP2 (receptor-activity-modifying protein) is a member of the RAMP family of single-transmembrane-domain proteins which consist of an N-terminal extracellular domain, a transmembrane region and a short intracellular C-terminal tail. RAMPs are required to transport calcitonin-receptor-like receptor (CRLR) to the plasma membrane. CRLR, a G protein-coupled receptor, can function as either a calcitonin gene-related peptide (CGRP) receptor or an adrenomedullin receptor, depending on which members of the RAMP family are expressed. RAMP1 transports the CRLR to the plasma membrane and then remains associated with it to function as a terminally glycosylated CGRP receptor, while RAMP2 and RAMP3 transfer the CRLR to the cell surface to generate receptors that are preferentially selective for adrenomedullin. (PMID: 9620797; 16188935)