Product Information
68560-1-PBS targets RAD51AP1 in WB, Indirect ELISA applications and shows reactivity with human, mouse samples.
| Tested Reactivity | human, mouse |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Immunogen | RAD51AP1 fusion protein Ag28385 Predict reactive species |
| Full Name | RAD51 associated protein 1 |
| Calculated Molecular Weight | 38 kDa |
| Observed Molecular Weight | 38-40 kDa |
| GenBank Accession Number | BC016330 |
| Gene Symbol | RAD51AP1 |
| Gene ID (NCBI) | 10635 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification Method | Protein A purification |
| UNIPROT ID | Q96B01 |
| Storage Buffer | PBS Only |
| Storage Conditions | Store at -80°C. |
Background Information
Homologous recombination (HR) is an important pathway for the elimination of DNA double-strand breaks (DSBs) and other deleterious lesions from chromosomes. The eukaryotic HR reaction is mediated by RAD51 [PMID:12456786]. RAD51AP1 (RAD51 associated protein 1), so named because it can interact with human RAD51, is a vertebrate-specific protein that enhances the ability of RAD51 to mediate the D-loop reaction. RAD51AP1 knockdown by siRNA leads to cellular sensitivity to DNA damaging agents and elevated DNA damage-induced chromatid breaks. Enhancement of the RAD51 recombinase activity by RAD51AP1 is contingent upon the physical interaction of the two HR factors [PMID:17996710,17996711].
