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RAD23A Polyclonal antibody, PBS Only

RAD23A Polyclonal Antibody for WB, Indirect ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse, rat

Applications

WB, Indirect ELISA

Conjugate

Unconjugated

Cat no : 11364-1-PBS

Synonyms

Validation Data Gallery

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  • Western Blot (WB) analysis of mouse testis tissue using RAD23A Polyclonal antibody (11364-1-AP)

    WB analysis of mouse testis using 11364-1-AP (same clone as 11364-1-PBS)

    mouse testis tissue were subjected to SDS PAGE followed by western blot with 11364-1-AP (RAD23A antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 11364-1-PBS in a different storage buffer formulation.

  • Western Blot (WB) analysis of mouse testis tissue using RAD23A Polyclonal antibody (11364-1-AP)

    WB analysis of mouse testis using 11364-1-AP (same clone as 11364-1-PBS)

    mouse testis tissue were subjected to SDS PAGE followed by western blot with 11364-1-AP (RAD23A antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 11364-1-PBS in a different storage buffer formulation.

Product Information

11364-1-PBS targets RAD23A in WB, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.

Tested Reactivity human, mouse, rat
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen RAD23A fusion protein Ag1907
Full Name RAD23 homolog A (S. cerevisiae)
Calculated Molecular Weight 40 kDa
Observed Molecular Weight 55 kDa
GenBank Accession NumberBC014026
Gene Symbol RAD23A
Gene ID (NCBI) 5886
Conjugate Unconjugated
Form Liquid
Purification MethodAntigen affinity purification
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.

Background Information

RAD23A, also named as HHR23A, belongs to the RAD23 family. It is a multiubiquitin chain receptor involved in modulation of proteasomal degradation. RAD23A binds to 'Lys-48'-linked polyubiquitin chains in a length-dependent manner and with a lower affinity to 'Lys-63'-linked polyubiquitin chains. It is proposed to be capable to bind simultaneously to the 26S proteasome and to polyubiquitinated substrates and to deliver ubiquitinated proteins to the proteasome. It is involved in nucleotide excision repair and is thought to be functional equivalent for RAD23B in global genome nucleotide excision repair (GG-NER) by association with XPC. In vitro, the XPC:RAD23A dimer has NER activity. Can stabilize XPC. It is also involved in vpr-dependent replication of HIV-1 in non-proliferating cells and primary macrophages and is required for the association of HIV-1 vpr with the host proteasome. This antibody is a rabbit polyclonal antibody raised against full length RAD23A of human origin.