QSOX1/Quiescin Q6 Recombinant antibody, PBS Only

QSOX1/Quiescin Q6 Uni-rAb^TM Recombinant Antibody for WB, ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

WB, ELISA

Conjugate

Unconjugated

CloneNo.

240946B11

Cat no : 83952-3-PBS

Synonyms

QSOX1, QSCN6, Q6, hQSOX, EC:1.8.3.2

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Validation Data Gallery

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  WB analysis using 83952-3-RR (same clone as 83952-3-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 83952-3-RR (QSOX1 antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 83952-3-PBS in a different storage buffer formulation.

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Product Information

The immunogen of 83952-3-PBS is QSOX1/Quiescin Q6 Fusion Protein expressed in E. coli.

• Tested Reactivity: human
• Host / Isotype: Rabbit / IgG
• Class: Recombinant
• Type: Antibody
• Immunogen: QSOX1/Quiescin Q6 fusion protein Ag3396
• Full Name: quiescin Q6 sulfhydryl oxidase 1
• Calculated Molecular Weight: 747 aa, 83 kDa
• Observed Molecular Weight: 66-83kDa
• GenBank Accession Number: BC017692
• Gene Symbol: QSOX1
• Gene ID (NCBI): 5768
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Protein A purfication
• Storage Buffer: PBS Only
• Storage Conditions: Store at -80°C.

Background Information

QSOX1(Sulfhydryl oxidase 1) catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide.It has two isoforms with the molecular weight of 67 kda and 83 kDa,respectively. It is detected a band of 95 Kda in HT1080 cell lines (PMID:17331072).Isoform 1 is expressed on golgi apparatus membrane and isoform 2 is secreted (PMID:10708601). The isoform1(QSOX1a) is the full length of QSOX1, approximately 78 kd; and the isoform2(QSOX1b) is the splicing form, approximately 62kd(PMID:14633699; 2496424). QSOX1 is highly expressed in tumor cell lines but is not expressed in adjacent normal cells (PMID:21989104).