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Protein Z Monoclonal antibody, PBS Only

Protein Z Monoclonal Antibody for WB, Indirect ELISA

Host / Isotype

Mouse / IgG2a

Reactivity

Human

Applications

WB, Indirect ELISA

Conjugate

Unconjugated

CloneNo.

2A1D3

Cat no : 68394-1-PBS

Synonyms

PROZ, PZ, Vitamin K dependent protein Z

Validation Data Gallery

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  • Western Blot (WB) analysis of various lysates using Protein Z Monoclonal antibody (68394-1-Ig)

    WB analysis using 68394-1-Ig (same clone as 68394-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 68394-1-Ig (Protein Z antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 68394-1-PBS in a different storage buffer formulation.

Product Information

68394-1-PBS targets Protein Z in WB, Indirect ELISA applications and shows reactivity with Human samples.

Tested Reactivity Human
Host / Isotype Mouse / IgG2a
Class Monoclonal
Type Antibody
Immunogen Protein Z fusion protein Ag13051
Full Name protein Z, vitamin K-dependent plasma glycoprotein
Calculated Molecular Weight 400 aa, 45 kDa
Observed Molecular Weight 45-47 kDa, 27 kDa
GenBank Accession NumberBC074906
Gene Symbol PROZ
Gene ID (NCBI) 8858
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purification
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.

Background Information

Protein Z (PZ, PROZ) is a vitamin K-dependent plasma protein that serves as a cofactor for activated factor X inhibition by the PZ-dependent protease inhibitor (PMID: 16938126). Reduced circulating levels of PZ have been suggested to play a role in the occurrence of bleeding (PMID: 7495103) and deep vein thrombosis (DVT) (PMID: 10829076), as well as in unexplained abortions with early fetal loss (PMID: 11895801), late fetal demise and intrauterine growth restriction (PMID: 16260213), acute coronary syndromes (PMID: 14652653), and stroke (PMID: 11570404). In addition, PZ may be a biomarker for the early diagnosis of pancreatic cancer (PMID: 31025496). It has two isoforms with molecular weights of 44 kDa and 47 kDa.