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Progranulin/PGRN Polyclonal antibody, PBS Only

Progranulin/PGRN Polyclonal Antibody for WB, Indirect ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse

Applications

WB, Indirect ELISA

Conjugate

Unconjugated

Cat no : 29491-1-PBS

Synonyms

granulin, Granulin-1, Granulin precursor, Glycoprotein of 88 Kda, Glycoprotein 88

Validation Data Gallery

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  • Western Blot (WB) analysis of various lysates using Progranulin/PGRN Polyclonal antibody (29491-1-AP)

    WB analysis using 29491-1-AP (same clone as 29491-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 29491-1-AP (Granulin antibody) at dilution of 1:1500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 29491-1-PBS in a different storage buffer formulation.

  • Western Blot (WB) analysis of various lysates using Progranulin/PGRN Polyclonal antibody (29491-1-AP)

    WB analysis using 29491-1-AP (same clone as 29491-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 29491-1-AP (Granulin antibody) at dilution of 1:2000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 29491-1-PBS in a different storage buffer formulation.

Product Information

29491-1-PBS targets Progranulin/PGRN in WB, Indirect ELISA applications and shows reactivity with human, mouse samples.

Tested Reactivity human, mouse
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen Progranulin/PGRN fusion protein Ag30723
Full Name granulin
Calculated Molecular Weight 64 kDa
Observed Molecular Weight70-75 kDa
GenBank Accession NumberBC000324
Gene Symbol Granulin
Gene ID (NCBI) 2896
Conjugate Unconjugated
Form Liquid
Purification MethodAntigen affinity purification
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.

Background Information

GRN, also known as PGRN or PCDGF, is a cysteine-rich protein of 68.5 kDa that is typically secreted into a highly glycosylated 88 kDa form. PGRN is a unique growth factor that plays an important role in cutaneous wound healing. It has an anti-inflammatory effect and promotes cell proliferation. When PCDGF is degraded to several 6-25 kDa fragments, called granulins (GRNs) by neutrophil proteases, a pro-inflammatory reaction occurs. PGRN is widely expressed, particularly in epithelial cells, immune cells, neurons, and chondrocytes. High levels of PGRN expression have been reported in human cancers, and its expression is closely correlated with the development and metastasis of several cancers. The recent discovery that mutations in the gene encoding for pro-granulin (GRN) cause frontotemporal lobar degeneration (FTLD), and other neurodegenerative diseases leading to dementia, has brought renewed interest in progranulin and its functions in the central nervous system.