Phospho-p38 MAPK (Thr180/Tyr182) Polyclonal antibody, PBS Only
Phospho-p38 MAPK (Thr180/Tyr182) Polyclonal Antibody for WB, IF/ICC, Indirect ELISA
Host / Isotype
Rabbit / IgG
Reactivity
human, mouse
Applications
WB, IF/ICC, Indirect ELISA
Conjugate
Unconjugated
Cat no : 28796-1-PBS
Synonyms
Validation Data Gallery
Product Information
28796-1-PBS targets Phospho-p38 MAPK (Thr180/Tyr182) in WB, IF/ICC, Indirect ELISA applications and shows reactivity with human, mouse samples.
Tested Reactivity | human, mouse |
Host / Isotype | Rabbit / IgG |
Class | Polyclonal |
Type | Antibody |
Immunogen | Peptide |
Full Name | mitogen-activated protein kinase 14 |
Calculated Molecular Weight | 360 aa, 41 kDa |
Observed Molecular Weight | 38-42 kDa |
GenBank Accession Number | BC031574 |
Gene Symbol | p38 MAPK |
Gene ID (NCBI) | 1432 |
Conjugate | Unconjugated |
Form | Liquid |
Purification Method | Antigen affinity purification |
Storage Buffer | PBS Only |
Storage Conditions | Store at -80°C. |
Background Information
A stress-activated serine/threonine protein kinase, p38 mitogen-activated protein kinase (p38 MAPK), belongs to the MAP kinase superfamily. Diverse extracellular stimuli, including ultraviolet light, irradiation, heat shock, high osmotic stress, proinflammatory cytokines and certain mitogens, trigger a stress-regulated protein kinase cascade culminating in activation of p38 MAPK through phosphorylation on a TGY motif within the kinase activation loop. The p38 MAPK undergoes dual phosphorylation at Thr182 and Tyr180 in the Thr-Gly-Tyr activation loop by MAP kinase kinase 6 (MKK6). Upon activation, p38 MAPK phosphorylates multiple substrates, including MAPK activated protein kinase 2 (MAPKAPK2) and activating transcription factor 2 (ATF-2). (PMID: 26901653, PMID: 10807318)