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Phospho-TBC1D1 (Ser707) Polyclonal antibody, PBS Only

Phospho-TBC1D1 (Ser707) Polyclonal Antibody for WB, Indirect ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

WB, Indirect ELISA

Conjugate

Unconjugated

Cat no : 29068-1-PBS

Synonyms

Validation Data Gallery

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  • Western Blot (WB) analysis of various lysates using Phospho-TBC1D1 (Ser707) Polyclonal antibody (29068-1-AP)

    WB analysis using 29068-1-AP (same clone as 29068-1-PBS)

    Non-treated and Calyculin A treated HEK-293T cells were subjected to SDS PAGE followed by western blot with 29068-1-AP (Phospho-TBC1D1 (Ser707) antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours. The membrane was stripped and re-blotted with Vinculin antibody as the loading control. This data was developed using the same antibody clone with 29068-1-PBS in a different storage buffer formulation.

This antibody is equivalent to Ser700 in mice.

Product Information

29068-1-PBS targets Phospho-TBC1D1 (Ser707) in WB, Indirect ELISA applications and shows reactivity with human samples.

Tested Reactivity human
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen Peptide
Full Name TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1
Calculated Molecular Weight 133 kDa
Observed Molecular Weight150-160 kDa
GenBank Accession NumberBC050321
Gene Symbol TBC1D1
Gene ID (NCBI) 23216
Conjugate Unconjugated
Form Liquid
Purification MethodAntigen affinity purification
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.

Background Information

TBC1D1 belong to the family of RabGAPs and its physiological roles in glucose homeostasis and its implication in human diseases have already been characterized in skeletal muscle and adipocytes in a large number of independent studies. TBC1D1 including twophospho-tyrosine-binding (PTB) domains, a calmodulin-binding domain(CBD) and the func-tional GAP domain responsible for catalyzing GTP hydrolysis. TBC1D1 is phosphorylated by AMPK at Ser660 and Thr237, and by AKT at Thr596. The RabGAPs TBC1D1 is important regulators of glucose homeostasis inskeletal muscle and adipose tissue. (PMID: 31627187, PMID: 18477703)