Product Information
68041-1-PBS targets Phospho-RPS6KA1 (Thr359/Ser363) in WB, IF/ICC, Indirect ELISA applications and shows reactivity with Human, Mouse samples.
Tested Reactivity | Human, Mouse |
Host / Isotype | Mouse / IgG1 |
Class | Monoclonal |
Type | Antibody |
Immunogen | Peptide Predict reactive species |
Full Name | ribosomal protein S6 kinase, 90kDa, polypeptide 1 |
Calculated Molecular Weight | 735 aa, 83 kDa |
Observed Molecular Weight | 80 kDa |
GenBank Accession Number | BC014966 |
Gene Symbol | RPS6KA1 |
Gene ID (NCBI) | 6195 |
RRID | AB_2918783 |
Conjugate | Unconjugated |
Form | Liquid |
Purification Method | Protein G purification |
UNIPROT ID | Q15418 |
Storage Buffer | PBS Only |
Storage Conditions | Store at -80°C. |
Background Information
The 90 kDa ribosomal S6 kinases (RSK1-4) are a family of widely expressed serine/threonine kinases and play an important role in the MAPK signaling cascade and act downstream of ERK1/2 signaling. It can mediate mitogenic and stress-induced activation of the transcription factors CREB1, ETV1/ER81 and NR4A1/NUR77. RSK1 (RPS6KA1) is also designated as p90RSK associated with cellular proliferation, survival and differentiation. RPS6KA1 has some phosphorylation sites including Ser380, Thr359 and Ser363 which are important for kinase activation. (PMID: 16458888, 30813401, 17259979, 10679322)