Phospho-NTRK1 (Tyr496) Recombinant antibody, PBS Only

Phospho-NTRK1 (Tyr496) Uni-rAb^TM Recombinant Antibody for WB, Indirect ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

WB, Indirect ELISA

Conjugate

Unconjugated

CloneNo.

241917B1

Cat no : 84976-1-PBS

Synonyms

NTRK1, Trk A, TRK, p140 TrkA, MTC

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Validation Data Gallery

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  WB analysis using 84976-1-RR (same clone as 84976-1-PBS)

  Non-treated and pervanadate treated HeLa cells were subjected to SDS PAGE followed by western blot with 84976-1-RR (Phospho-NTRK1 (Tyr496) antibody) at dilution of 1:3000 incubated at room temperature for 1.5 hours. The membrane was stripped and re-blotted with Vinculin (66305-1-Ig) antibody as a loading control. This data was developed using the same antibody clone with 84976-1-PBS in a different storage buffer formulation.

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Product Information

84976-1-PBS targets Phospho-NTRK1 (Tyr496) in WB, Indirect ELISA applications and shows reactivity with human samples.

• Tested Reactivity: human
• Host / Isotype: Rabbit / IgG
• Class: Recombinant
• Type: Antibody
• Immunogen: Peptide
• Full Name: neurotrophic tyrosine kinase, receptor, type 1
• Observed Molecular Weight: 140 kDa
• GenBank Accession Number: BC062580
• Gene Symbol: NTRK1
• Gene ID (NCBI): 4914
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Protein A purfication
• Storage Buffer: PBS Only
• Storage Conditions: Store at -80°C.

Background Information

The tyrosine kinase receptor TrkA (or neurotrophin receptor kinase 1, NTRK1) has been predominately studied for its role during the development of the nervous system. In developing neurons, TrkA activation upon binding of its ligands nerve growth factor (NGF) or neurotrophin-3 (NT-3) results in the stimulation of various tyrosine kinase-induced signaling pathways leading to neuronal outgrowth. (PMID: 32957504) This antibody recognizes the phosphorylation of TrkA at site 496, which is the phosphorylation of the isoform 2 sequence at site 490.