Phospho-Beta Catenin (Ser37) Polyclonal antibody
Phospho-Beta Catenin (Ser37) Polyclonal Antibody for WB, ELISA
Host / Isotype
Rabbit / IgG
Reactivity
Human and More (1)
Applications
WB, ELISA
Conjugate
Unconjugated
Cat no : 28776-1-AP
Synonyms
Validation Data Gallery
Tested Applications
Positive WB detected in | Calyculin A treated HeLa cells |
Recommended dilution
Application | Dilution |
---|---|
Western Blot (WB) | WB : 1:500-1:1000 |
It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
Sample-dependent, Check data in validation data gallery. |
Published Applications
WB | See 1 publications below |
Product Information
28776-1-AP targets Phospho-Beta Catenin (Ser37) in WB, ELISA applications and shows reactivity with Human samples.
Tested Reactivity | Human |
Cited Reactivity | human |
Host / Isotype | Rabbit / IgG |
Class | Polyclonal |
Type | Antibody |
Immunogen | Peptide |
Full Name | catenin (cadherin-associated protein), beta 1, 88kDa |
Calculated Molecular Weight | 781 aa, 86 kDa |
Observed Molecular Weight | 86-100 kDa |
GenBank Accession Number | BC058926 |
Gene Symbol | Beta Catenin |
Gene ID (NCBI) | 1499 |
Conjugate | Unconjugated |
Form | Liquid |
Purification Method | Antigen affinity purification |
Storage Buffer | PBS with 0.02% sodium azide and 50% glycerol pH 7.3. |
Storage Conditions | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. 20ul sizes contain 0.1% BSA. |
Background Information
Beta Catenin(β-catenin), also known as CTNNB1, is an evolutionarily conserved, multifunctional intracellular protein. β-catenin is a key downstream component of the canonical Wnt pathway that plays diverse and critical roles in embryonic development and adult tissue homeostasis.Deregulation of β-catenin activity is associated with multiple diseases including cancers. The N-terminal (1-49 amino acids) of β-catenin is the key region for its stability and the degradation by ubiquitin-proteasome system, and phosphorylation of β-catenin at the N-terminal Ser33, Ser37, Thr41, and Ser45 promotes its ubiquitination and degradation(PMID: 31930681).
Protocols
Product Specific Protocols | |
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WB protocol for Phospho-Beta Catenin (Ser37) antibody 28776-1-AP | Download protocol |
Standard Protocols | |
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Click here to view our Standard Protocols |
Publications
Species | Application | Title |
---|---|---|
J Agric Food Chem Ursolic Acid Suppresses Colorectal Cancer by Down-Regulation of Wnt/β-Catenin Signaling Pathway Activity |