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PTPRK Polyclonal antibody, PBS Only

PTPRK Polyclonal Antibody for WB, Indirect ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse, rat

Applications

WB, Indirect ELISA

Conjugate

Unconjugated

Cat no : 28151-1-PBS

Synonyms

Validation Data Gallery

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  • Western Blot (WB) analysis of various lysates using PTPRK Polyclonal antibody (28151-1-AP)

    WB analysis using 28151-1-AP (same clone as 28151-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 28151-1-AP (PTPRK antibody) at dilution of 1:800 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 28151-1-PBS in a different storage buffer formulation.

  • Western Blot (WB) analysis of various lysates using PTPRK Polyclonal antibody (28151-1-AP)

    WB analysis using 28151-1-AP (same clone as 28151-1-PBS)

    mouse spleen tissue were subjected to SDS PAGE followed by western blot with 28151-1-AP (PTPRK antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 28151-1-PBS in a different storage buffer formulation.

Product Information

28151-1-PBS targets PTPRK in WB, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.

Tested Reactivity human, mouse, rat
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen PTPRK fusion protein Ag27765
Full Name protein tyrosine phosphatase, receptor type, K
Calculated Molecular Weight 1439 aa, 162 kDa
Observed Molecular Weight 100-120 kDa
GenBank Accession NumberBC140775
Gene Symbol PTPRK
Gene ID (NCBI) 5796
Conjugate Unconjugated
Form Liquid
Purification MethodAntigen affinity purification
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.

Background Information

PTPRK (Protein Tyrosine Phosphatase Receptor Type Kappa), a member of the receptor-type protein tyrosine phosphatase family, is a transmembrane protein that regulates cell-cell contact. PTPRK is a 210 kDa precursor protein and converted by furin to a mature heterodimeric protein composed of a non-covalently attached amino-terminal extracellular subunit (E-subunit, 120 kDa) and carboxyl-terminal transmembrane subunit (P-subunit, 95 kDa) (PMID: 24882578, 16648485). Loss of PTPRK activity has been observed in pancreatic cancer, primary CNS lymphoma and melanoma, and is associated with poor survival of cancer patients, which suggest that PTPRK is a potential tumor suppressor (PMID: 23696788).