PTPN4 Polyclonal antibody

PTPN4 Polyclonal Antibody for WB, ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

WB, ELISA

Conjugate

Unconjugated

Publications

1

Cat no : 11131-1-AP

Synonyms

MEG, PTPase MEG1, PTPMEG, PTPMEG1, PTPN4

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Validation Data Gallery

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  WB analysis using 11131-1-AP

  Various lysates were subjected to SDS PAGE followed by western blot with 11131-1-AP (PTPN4 antibody) at dilution of 1:2000 incubated at room temperature for 1.5 hours.

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Tested Applications

• Positive WB detected in: K-562 cells, SH-SY5Y cells

Recommended dilution

• Western Blot (WB): WB : 1:1000-1:4000

It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Sample-dependent, Check data in validation data gallery.

Published Applications

• WB: See 1 publications below

Product Information

11131-1-AP targets PTPN4 in WB, ELISA applications and shows reactivity with human samples.

• Tested Reactivity: human
• Cited Reactivity: human
• Host / Isotype: Rabbit / IgG
• Class: Polyclonal
• Type: Antibody
• Immunogen: PTPN4 fusion protein Ag1585
• Full Name: protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte)
• Calculated Molecular Weight: 106 kDa
• Observed Molecular Weight: 106 kDa
• GenBank Accession Number: BC010674
• Gene Symbol: PTPN4
• Gene ID (NCBI): 5775
• RRID: AB_2173540
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Antigen affinity purification
• Storage Buffer: PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
• Storage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20^oC storage. 20ul sizes contain 0.1% BSA.

Background Information

PTPN4 is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This protein contains a C-terminal PTP domain and an N-terminal domain homologous to the band 4.1 superfamily of cytoskeletal-associated proteins. This PTP has been shown to interact with glutamate receptor delta 2 and epsilon subunits, and is thought to play a role in signalling downstream of the glutamate receptors through tyrosine dephosphorylation.

Publications

Species	Application	Title
human	WB	Aging (Albany NY); LncRNA SH3BP5-AS1 promotes hepatocellular carcinoma progression by sponging miR-6838-5p and activation of PTPN4; Authors - Xinyang Zhao