PTPN22 Polyclonal antibody

PTPN22 Polyclonal Antibody for WB, IP, IHC, ELISA

Host / Isotype

Rabbit / IgG


human, mouse, rat





Cat no : 11783-1-AP


Lymphoid phosphatase, LYP, LYP1, LYP2, PEP, PTPN22, PTPN8

Tested Applications

Positive WB detected inDaudi cells, Raji cells, Jurkat cells
Positive IP detected inJurkat cells
Positive IHC detected inhuman lymphoma tissue
Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0

Recommended dilution

Western Blot (WB)WB : 1:500-1:2000
Immunoprecipitation (IP)IP : 0.5-4.0 ug for 1.0-3.0 mg of total protein lysate
Immunohistochemistry (IHC)IHC : 1:50-1:500
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

Product Information

11783-1-AP targets PTPN22 in WB, IP, IF, IHC, ELISA applications and shows reactivity with human, mouse, rat samples.

Tested Reactivity human, mouse, rat
Cited Reactivityhuman, mouse, rat
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen PTPN22 fusion protein Ag2397
Full Name protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
Calculated Molecular Weight 82 kDa, 92 kDa
Observed Molecular Weight 100-110 kDa
GenBank Accession NumberBC017785
Gene Symbol PTPN22
Gene ID (NCBI) 26191
Conjugate Unconjugated
Form Liquid
Purification MethodAntigen affinity purification
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. 20ul sizes contain 0.1% BSA.

Background Information

PTPN22(Tyrosine-protein phosphatase non-receptor type 22) is also named as LyP,PEP,PTPN8.It belongs to the protein-tyrosine phosphatase family and non-receptor class 4 subfamily.It acts as negative regulator of T-cell receptor (TCR) signaling.Defects in PTPN22 are a cause of susceptibility to systemic lupus erythematosus (SLE). It has some isoforms produced by alternative splicing with calculated molecular mass of 79-92 kDa, and apparent molecular mass of 100-110 kDa.


Product Specific Protocols
WB protocol for PTPN22 antibody 11783-1-APDownload protocol
IHC protocol for PTPN22 antibody 11783-1-APDownload protocol
IP protocol for PTPN22 antibody 11783-1-APDownload protocol
Standard Protocols
Click here to view our Standard Protocols



J Exp Med

NLR Nod1 signaling promotes survival of BCR-engaged mature B cells through up-regulated Nod1 as a positive outcome.

Authors - Kyoko Hayakawa

Sci Signal

The adaptor protein TRAF3 inhibits interleukin-6 receptor signaling in B cells to limit plasma cell development.

Authors - Wai W Lin

Sci Rep

TRAF3 enhances TCR signaling by regulating the inhibitors Csk and PTPN22.

Authors - Alicia M Wallis

Pflugers Arch

Anandamide produced by Ca(2+)-insensitive enzymes induces excitation in primary sensory neurons.

Authors - Varga Angelika A