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  • Featured Product
  • KD/KO Validated

PTPMT1 Polyclonal antibody, PBS Only

PTPMT1 Polyclonal Antibody for WB, IHC, Indirect ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse, rat

Applications

WB, IHC, Indirect ELISA

Conjugate

Unconjugated

Cat no : 11493-1-PBS

Synonyms

Validation Data Gallery

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  • Western Blot (WB) analysis of mouse pancreas tissue using PTPMT1 Polyclonal antibody (11493-1-AP)

    WB analysis of mouse pancreas using 11493-1-AP (same clone as 11493-1-PBS)

    mouse pancreas tissue were subjected to SDS PAGE followed by western blot with 11493-1-AP (PTPMT1 antibody) at dilution of 1:300 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 11493-1-PBS in a different storage buffer formulation.

  • Western Blot (WB) analysis of rat pancreas tissue using PTPMT1 Polyclonal antibody (11493-1-AP)

    WB analysis of rat pancreas using 11493-1-AP (same clone as 11493-1-PBS)

    rat pancreas tissue were subjected to SDS PAGE followed by western blot with 11493-1-AP (PTPMT1 antibody) at dilution of 1:600 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 11493-1-PBS in a different storage buffer formulation.

  • Immunohistochemistry (IHC) staining of human pancreas cancer tissue using PTPMT1 Polyclonal antibody (11493-1-AP)

    IHC staining of human pancreas cancer using 11493-1-AP (same clone as 11493-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human pancreas cancer using 11493-1-AP (PTPMT1 antibody) at dilution of 1:50 (under 10x lens). This data was developed using the same antibody clone with 11493-1-PBS in a different storage buffer formulation.

Product Information

11493-1-PBS targets PTPMT1 in WB, IHC, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.

Tested Reactivity human, mouse, rat
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen PTPMT1 fusion protein Ag2063
Full Name protein tyrosine phosphatase, mitochondrial 1
Calculated Molecular Weight 201 aa, 23 kDa
Observed Molecular Weight 21-23 kDa
GenBank Accession NumberBC020242
Gene Symbol PTPMT1
Gene ID (NCBI) 114971
Conjugate Unconjugated
Form Liquid
Purification MethodAntigen affinity purification
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.

Background Information

Protein Tyrosine Phosphatase localized to the Mitochondrial 1 (PTPMT1) is a highly conserved, dual-specific phosphatase that resides on the matrix-facing side of the inner mitochondrial membrane (IMM). PTPMT1 is a mitochondrial phosphatase and a vital regulator of mitochondrial activities. Current work points to roles for PTPMT1 in the regulation of mitochondrial respiration, dynamics, and ultrastructure through the modulation of pyruvate importation, the tuning of TCA cycle activity, and the synthesis of cardiolipin. PTPMT1 is highly expressed in pancreatic b cells, whose mitochondria have the important function of coupling glucose metabolism to the secretion of insulin. (PMID: 16337125, PMID: 16061174, PMID: 33335799)