PTPMT1 Polyclonal antibody, PBS Only

• 

  WB analysis of mouse pancreas using 11493-1-AP (same clone as 11493-1-PBS)

  mouse pancreas tissue were subjected to SDS PAGE followed by western blot with 11493-1-AP (PTPMT1 antibody) at dilution of 1:300 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 11493-1-PBS in a different storage buffer formulation.

• 

  WB analysis of rat pancreas using 11493-1-AP (same clone as 11493-1-PBS)

  rat pancreas tissue were subjected to SDS PAGE followed by western blot with 11493-1-AP (PTPMT1 antibody) at dilution of 1:600 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 11493-1-PBS in a different storage buffer formulation.

• 

  IHC staining of human pancreas cancer using 11493-1-AP (same clone as 11493-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human pancreas cancer using 11493-1-AP (PTPMT1 antibody) at dilution of 1:50 (under 10x lens). This data was developed using the same antibody clone with 11493-1-PBS in a different storage buffer formulation.

• Featured Product
• KD/KO Validated

PTPMT1 Polyclonal Antibody for WB, IHC, Indirect ELISA

Cat No. 11493-1-PBS

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse, rat

Applications

WB, IHC, Indirect ELISA

Synonyms

---

Product Information

11493-1-PBS targets PTPMT1 in WB, IHC, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.

• Tested Reactivity: human, mouse, rat
• Host / Isotype: Rabbit / IgG
• Class: Polyclonal
• Type: Antibody
• Immunogen: PTPMT1 fusion protein Ag2063
• Full Name: protein tyrosine phosphatase, mitochondrial 1
• Calculated Molecular Weight: 201 aa, 23 kDa
• Observed Molecular Weight: 21-23 kDa
• GenBank Accession Number: BC020242
• Gene Symbol: PTPMT1
• Gene ID (NCBI): 114971
• RRID: AB_2237967
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Antigen affinity purification
• UNIPROT ID: Q8WUK0
• Storage Buffer: PBS Only
• Storage Conditions: Store at -80°C.

Background Information

Protein Tyrosine Phosphatase localized to the Mitochondrial 1 (PTPMT1) is a highly conserved, dual-specific phosphatase that resides on the matrix-facing side of the inner mitochondrial membrane (IMM). PTPMT1 is a mitochondrial phosphatase and a vital regulator of mitochondrial activities. Current work points to roles for PTPMT1 in the regulation of mitochondrial respiration, dynamics, and ultrastructure through the modulation of pyruvate importation, the tuning of TCA cycle activity, and the synthesis of cardiolipin. PTPMT1 is highly expressed in pancreatic b cells, whose mitochondria have the important function of coupling glucose metabolism to the secretion of insulin. (PMID: 16337125, PMID: 16061174, PMID: 33335799)