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PSMD14/POH1 Recombinant antibody, PBS Only

PSMD14/POH1 Uni-rAbTM Recombinant Antibody for IF/ICC, Indirect ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

IF/ICC, Indirect ELISA

Conjugate

Unconjugated

CloneNo.

242160H6

Cat no : 84767-4-PBS

Synonyms

PSMD14, POH1, PAD1, EC:3.4.19.-, 26S proteasome-associated PAD1 homolog 1

Validation Data Gallery

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  • Immunofluorescence (IF) / fluorescent staining of A375 cells using PSMD14/POH1 Recombinant antibody (84767-4-RR)

    IF Staining of A375 using 84767-4-RR (same clone as 84767-4-PBS)

    Immunofluorescent analysis of (4% PFA) fixed A375 cells using PSMD14 antibody (84767-4-RR, Clone: 242160H6 ) at dilution of 1:250 and CoraLite®488-Conjugated Goat Anti-Rabbit IgG(H+L) (SA00013-2), CL594-Phalloidin (red). This data was developed using the same antibody clone with 84767-4-PBS in a different storage buffer formulation.

Product Information

84767-4-PBS targets PSMD14/POH1 in IF/ICC, Indirect ELISA applications and shows reactivity with human samples.

Tested Reactivity human
Host / Isotype Rabbit / IgG
Class Recombinant
Type Antibody
Immunogen PSMD14/POH1 fusion protein Ag2694
Full Name proteasome (prosome, macropain) 26S subunit, non-ATPase, 14
Calculated Molecular Weight 35 kDa
GenBank Accession NumberBC009524
Gene Symbol PSMD14
Gene ID (NCBI) 10213
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purfication
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.

Background Information

The PSMD14 (POH1, also known as Rpn11/MPR1/S13/CepP1) protein is a metalloprotease component of the 26S proteasome that specifically cleaves 'Lys-63'-linked polyubiquitin chains. The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. PSMD14 is highly expressed in the heart and skeletal muscle. In carcinoma cell lines. down-regulation of PSMD14 by siRNA transfection considerably impacted cell viability, causing cell arrest in the G0-G1 phase, ultimately leading to senescence.