PPP3CA-specific Polyclonal antibody, PBS Only

• 

  WB analysis of mouse brain using 55147-1-AP (same clone as 55147-1-PBS)

  mouse brain tissue were subjected to SDS PAGE followed by western blot with 55147-1-AP (PPP3CA-specific antibody) at dilution of 1:300 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 55147-1-PBS in a different storage buffer formulation.

• 

  WB analysis of mouse pancreas using 55147-1-AP (same clone as 55147-1-PBS)

  mouse pancreas tissue were subjected to SDS PAGE followed by western blot with 55147-1-AP (PPP3CA-specific antibody) at dilution of 1:300 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 55147-1-PBS in a different storage buffer formulation.

PPP3CA-specific Polyclonal Antibody for WB, Indirect ELISA

Cat No. 55147-1-PBS

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse

Applications

WB, Indirect ELISA

Synonyms

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Product Information

55147-1-PBS targets PPP3CA-specific in WB, Indirect ELISA applications and shows reactivity with human, mouse samples.

• Tested Reactivity: human, mouse
• Host / Isotype: Rabbit / IgG
• Class: Polyclonal
• Type: Antibody
• Immunogen: Peptide
• Full Name: protein phosphatase 3 (formerly 2B), catalytic subunit, alpha isoform
• Calculated Molecular Weight: 59 kDa
• Observed Molecular Weight: 59 kDa
• GenBank Accession Number: NM_000944
• Gene Symbol: PPP3CA
• Gene ID (NCBI): 5530
• RRID: AB_10858786
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Antigen affinity purification
• UNIPROT ID: Q08209
• Storage Buffer: PBS only , pH 7.3
• Storage Conditions: Store at -80°C.

Background Information

PPP3CA, also called calcineurin Aα, is the only serine/threonine protein phosphatase under the control of Ca2+/calmodulin, and plays a critical role in the coupling of Ca2+ signals to cellular responses. Ca2+ signaling plays a central role in hypertrophic growth of cardiac and skeletal muscle in response to mechanical load and a variety of signals. Therefore, PPP3CA plays an important role in muscle differentiation, especially in muscle fiber type conversion. It is also involved in osteoclast regulation, regulating bone formation through an effect on osteoblast differentiation. This antibody is specific to PPP3CA.