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PGC1a Polyclonal antibody

PGC1a Polyclonal Antibody for ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse and More (4)

Applications

WB, IHC, IF, chIP, ELISA

Conjugate

Unconjugated

Cat no : 20658-1-AP

Synonyms



Tested Applications

Recommended dilution

ApplicationDilution
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, check data in validation data gallery

Product Information

20658-1-AP targets PGC1a in WB, IHC, IF, chIP, ELISA applications and shows reactivity with human, mouse samples.

Tested Reactivity human, mouse
Cited Reactivityhuman, mouse, rat, goat, chicken, zebrafish
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen Peptide
Full Name peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
Calculated molecular weight 91 kDa
Observed molecular weight 91-98 kDa
GenBank accession numberNM_013261
Gene symbol PPARGC1A
Gene ID (NCBI) 10891
Conjugate Unconjugated
Form Liquid
Purification Method Antigen affinity purification
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. 20ul sizes contain 0.1% BSA.

Background Information

PPARGC1A, also named as Peroxisome proliferator-activated receptor gamma coactivator 1-alpha, is a 798 amino acid protein, which Contains 1 RRM (RNA recognition motif) domain and localizes in the nucleus. PPARGC1A is transcriptional coactivator for steroid receptors and nuclear receptors. PPARGC1A can regulate key mitochondrial genes that contribute to the program of adaptive thermogenesis and plays an essential role in metabolic reprogramming in response to dietary availability through coordination of the expression of a wide array of genes involved in glucose and fatty acid metabolism. PPARGC1A exists various isoforms and range of molecular weight of isoforms are 30-50 kDa and 90-110 kDa.

Publications

SpeciesApplicationTitle

Mol Cell

AUTACs: Cargo-Specific Degraders Using Selective Autophagy.

Authors - Daiki Takahashi
humanWB

Redox Biol

Defective mitochondrial ISCs biogenesis switches on IRP1 to fine tune selective mitophagy.

Authors - Hao Wu
mouseWB

Autophagy

FOXG1 promotes aging inner ear hair cell survival through activation of the autophagy pathway.

Authors - Zu-Hong He
ratWB

Part Fibre Toxicol

Carbon black suppresses the osteogenesis of mesenchymal stem cells: the role of mitochondria.

Authors - Yulai Shen
mouseWB,IHC

Oxid Med Cell Longev

Recombinant Human Growth Hormone Inhibits Lipotoxicity, Oxidative Stress, and Apoptosis in a Mouse Model of Diabetic Cardiomyopathy.

Authors - Zuowei Pei
ratWB

Redox Biol

Cardioprotection of CAPE-oNO2 against myocardial ischemia/reperfusion induced ROS generation via regulating the SIRT1/eNOS/NF-κB pathway in vivo and in vitro.

Authors - Dejuan Li