- Featured Product
- KD/KO Validated
PGC1a Polyclonal antibody
PGC1a Polyclonal Antibody for ELISA
Host / Isotype
Rabbit / IgG
Reactivity
human, mouse and More (4)
Applications
WB, IHC, IF, chIP, ELISA
Conjugate
Unconjugated
Cat no : 20658-1-AP
Synonyms
Validation Data Gallery
Tested Applications
Recommended dilution
| Application | Dilution |
|---|---|
| Sample-dependent, check data in validation data gallery | |
Published Applications
| KD/KO | See 2 publications below |
| WB | See 38 publications below |
| IHC | See 8 publications below |
| IF | See 5 publications below |
| ChIP | See 1 publications below |
Product Information
20658-1-AP targets PGC1a in WB, IHC, IF, chIP, ELISA applications and shows reactivity with human, mouse samples.
| Tested Reactivity | human, mouse |
| Cited Reactivity | human, mouse, rat, chicken, goat, zebrafish |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Peptide |
| Full Name | peroxisome proliferator-activated receptor gamma, coactivator 1 alpha |
| Calculated molecular weight | 91 kDa |
| Observed molecular weight | 91-98 kDa |
| GenBank accession number | NM_013261 |
| Gene symbol | PPARGC1A |
| Gene ID (NCBI) | 10891 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification Method | Antigen affinity purification |
| Storage Buffer | PBS with 0.02% sodium azide and 50% glycerol pH 7.3. |
| Storage Conditions | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. |
Background Information
PPARGC1A, also named as Peroxisome proliferator-activated receptor gamma coactivator 1-alpha, is a 798 amino acid protein, which Contains 1 RRM (RNA recognition motif) domain and localizes in the nucleus. PPARGC1A is transcriptional coactivator for steroid receptors and nuclear receptors. PPARGC1A can regulate key mitochondrial genes that contribute to the program of adaptive thermogenesis and plays an essential role in metabolic reprogramming in response to dietary availability through coordination of the expression of a wide array of genes involved in glucose and fatty acid metabolism. PPARGC1A exists various isoforms and range of molecular weight of isoforms are 30-50 kDa and 90-110 kDa.
Publications
| Species | Application | Title |
|---|---|---|
Cardiovasc Res Cardiomyocyte-specific loss of RMP causes myocardial dysfunction and heart failure. | ||
PLoS Biol Organic cation transporter 3 (Oct3) is a distinct catecholamines clearance route in adipocytes mediating the beiging of white adipose tissue. | ||
Stress Regulating glycolysis, the TLR4 signal pathway and expression of RBM3 in mouse liver in response to acute cold exposure. | ||
Nat Commun The SIAH2-NRF1 axis spatially regulates tumor microenvironment remodeling for tumor progression. | ||
Theranostics SIRT3-Dependent Mitochondrial Dynamics Remodeling Contributes to Oxidative Stress-Induced Melanocyte Degeneration in Vitiligo. | ||
Mol Biosyst Metabolomics reveal mitochondrial and fatty acid metabolism disorders that contribute to the development of DKD in T2DM patients. |
