PON3 Polyclonal antibody, PBS Only

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  WB analysis using 31793-1-AP (same clone as 31793-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 31793-1-AP (PON3 antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 31793-1-PBS in a different storage buffer formulation.

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  IHC staining of mouse liver using 31793-1-AP (same clone as 31793-1-PBS)

  Immunohistochemical analysis of paraffin-embedded mouse liver tissue slide using 31793-1-AP (PON3 antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 31793-1-PBS in a different storage buffer formulation.

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  IHC staining of human liver using 31793-1-AP (same clone as 31793-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human liver tissue slide using 31793-1-AP (PON3 antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 31793-1-PBS in a different storage buffer formulation.

• 

  IHC staining of human liver using 31793-1-AP (same clone as 31793-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human liver tissue slide using 31793-1-AP (PON3 antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 31793-1-PBS in a different storage buffer formulation.

• 

  IHC staining of rat liver using 31793-1-AP (same clone as 31793-1-PBS)

  Immunohistochemical analysis of paraffin-embedded rat liver tissue slide using 31793-1-AP (PON3 antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 31793-1-PBS in a different storage buffer formulation.

• 

  IHC staining of rat liver using 31793-1-AP (same clone as 31793-1-PBS)

  Immunohistochemical analysis of paraffin-embedded rat liver tissue slide using 31793-1-AP (PON3 antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 31793-1-PBS in a different storage buffer formulation.

• 

  IHC staining of mouse liver using 31793-1-AP (same clone as 31793-1-PBS)

  Immunohistochemical analysis of paraffin-embedded mouse liver tissue slide using 31793-1-AP (PON3 antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 31793-1-PBS in a different storage buffer formulation.

PON3 Polyclonal Antibody for WB, IHC, Indirect ELISA

Cat No. 31793-1-PBS

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse, rat

Applications

WB, IHC, Indirect ELISA

Synonyms

Paraoxonase 3 , Paraoxanase-3, EC:3.1.8.1

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Product Information

31793-1-PBS targets PON3 in WB, IHC, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.

• Tested Reactivity: human, mouse, rat
• Host / Isotype: Rabbit / IgG
• Class: Polyclonal
• Type: Antibody
• Immunogen: PON3 fusion protein Ag36602
• Full Name: paraoxonase 3
• Calculated Molecular Weight: NM_000940.2 40kDa，354aa
• Observed Molecular Weight: 40 kDa
• GenBank Accession Number: NM_000940.2
• Gene Symbol: PON3
• Gene ID (NCBI): 5446
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Antigen affinity Purification
• UNIPROT ID: Q15166
• Storage Buffer: PBS only , pH 7.3
• Storage Conditions: Store at -80°C.

Background Information

PON3, a member of the paraoxonase family, is expressed primarily in the liver and encodes a protein that is secreted into the bloodstream and binds to high-density lipoprotein (HDL). It also rapidly hydrolyzes lactones and inhibits the oxidation of low-density lipoprotein (LDL), thereby slowing the onset and progression of atherosclerosis. In addition, PON3 is closely associated with hepatocellular carcinoma (HCC), and is a potential therapeutic target for HCC by inducing cell cycle arrest and further inhibiting HCC cell proliferation.