PLA2R1 Polyclonal antibody

• Featured Product
• KD/KO Validated

PLA2R1 Polyclonal Antibody for ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

WB, ELISA

Conjugate

Unconjugated

Publications

1

Cat no : 18798-1-AP

Synonyms

CLEC13C, M type receptor, PLA2 R, PLA2G1R, PLA2IR, PLA2R, PLA2R1, Soluble PLA2 R, Soluble PLA2R

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Validation Data Gallery

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  IHC staining of human pancreas using 18798-1-AP

  Immunohistochemical analysis of paraffin-embedded human pancreas tissue slide using 18798-1-AP (PLA2R1 Antibody) at dilution of 1:100 (under 10x lens).

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  IHC staining of human pancreas using 18798-1-AP

  Immunohistochemical analysis of paraffin-embedded human pancreas tissue slide using 18798-1-AP (PLA2R1 Antibody) at dilution of 1:100 (under 40x lens).

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Published Applications

• KD/KO: See 1 publications below
• WB: See 1 publications below

Product Information

18798-1-AP targets PLA2R1 in WB, ELISA applications and shows reactivity with human samples.

• Tested Reactivity: human
• Cited Reactivity: human
• Host / Isotype: Rabbit / IgG
• Class: Polyclonal
• Type: Antibody
• Immunogen: Peptide
• Full Name: phospholipase A2 receptor 1, 180kDa
• Calculated Molecular Weight: 168 kDa
• GenBank Accession Number: BC144631
• Gene Symbol: PLA2R1
• Gene ID (NCBI): 22925
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Antigen affinity purification
• Storage Buffer: PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
• Storage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20^oC storage. 20ul sizes contain 0.1% BSA.

Background Information

Secretory phospholipase A2 (sPLA2) are implicated in a number of crucial physiological and pathological processes in mammals. Different types of membrane receptors for sPLA2s have been identified. The M-type receptor, PLA2R1 (phospholipase A2 receptor 1, 180 kDa), is a type I transmembrane glycoprotein containing extracellularly a cysteine-rich domain, a fibronectin type II domain and eight carbohydrate-recognition domains. It is a receptor for phosholipase sPLA2-IB/PLA2G1B but not sPLA2-IIA/PLA2G2A. It is also able to bind to snake PA2-like toxins. PLA2R1 may be involved in responses in proinflammatory cytokine productions during endotoxic shock. It also has endocytic properties and rapidly internalizes sPLA2 ligands, which is particularly important for the clearance of extracellular sPLA2s to protect their potent enzymatic activities. It has been recently shown that PLA2R1 is the major target antigen in idiopathic membranous nephropathy (iMN). Patients with iMN have antibodies against a conformation-dependent epitope in PLA2R1.

Publications

Species	Application	Title
human	WB	Mol Pharm; Role of the Phospholipase A2 Receptor in Liposome Drug Delivery in Prostate Cancer Cells.; Authors - N D Quach ; KD Validated