- Featured Product
- KD/KO Validated
PIN1 Recombinant antibody, PBS Only
PIN1 Uni-rAbTM Recombinant Antibody for WB, IHC, IF/ICC, IP, Indirect ELISA
Host / Isotype
Rabbit / IgG
Reactivity
human, mouse, rat, pig
Applications
WB, IHC, IF/ICC, IP, Indirect ELISA
Conjugate
Unconjugated
CloneNo.
5N20
Cat no : 81857-1-PBS
Synonyms
Validation Data Gallery
Product Information
81857-1-PBS targets PIN1 in WB, IHC, IF/ICC, IP, Indirect ELISA applications and shows reactivity with human, mouse, rat, pig samples.
Tested Reactivity | human, mouse, rat, pig |
Host / Isotype | Rabbit / IgG |
Class | Recombinant |
Type | Antibody |
Immunogen | PIN1 fusion protein Ag0767 |
Full Name | peptidylprolyl cis/trans isomerase, NIMA-interacting 1 |
Calculated Molecular Weight | 18 kDa |
Observed Molecular Weight | 18 kDa |
GenBank Accession Number | BC002899 |
Gene Symbol | PIN1 |
Gene ID (NCBI) | 5300 |
Conjugate | Unconjugated |
Form | Liquid |
Purification Method | Protein A purification |
Storage Buffer | PBS Only |
Storage Conditions | Store at -80°C. |
Background Information
PIN1(Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1) is essential for mitosis progression in yeast cells and is hypothesized to perform the same role in mammalian cells. It might regulate cellular processes distinct from the cell cycle itself, such as terminal differentiation through a modulation of differentiation-specific gene expression(PMID:20801874). It colocalizes with NEK6 in the nucleus. Pin1 inhibition simultaneously blocks multiple cancer pathways, disrupts the desmoplastic and immunosuppressive TME, and upregulates PD-L1 and ENT1, rendering pancreatic ductal adenocarcinoma (PDAC) eradicable by immunochemotherapy (PMID: 34388391).