PDE4D Monoclonal antibody, PBS Only

PDE4D Monoclonal Antibody for WB, IF/ICC, Indirect ELISA
Cat No. 67062-1-PBS
Clone No.1C4B9

Host / Isotype

Mouse / IgG1

Reactivity

human, mouse, rat, pig

Applications

WB, IF/ICC, Indirect ELISA

PDE43, EC:3.1.4.53, DPDE3, cAMP-specific phosphodiesterase 4D, 3',5'-cyclic-AMP phosphodiesterase 4D

Formulation:  PBS Only
PBS and Azide
PBS Only
Conjugate:  Unconjugated
Size/Concentration: 

-/ -

Freight/Packing: -

Quantity

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Product Information

67062-1-PBS targets PDE4D in WB, IF/ICC, Indirect ELISA applications and shows reactivity with human, mouse, rat, pig samples.

Tested Reactivity human, mouse, rat, pig
Host / Isotype Mouse / IgG1
Class Monoclonal
Type Antibody
Immunogen PDE4D fusion protein Ag8302 Predict reactive species
Full Name phosphodiesterase 4D, cAMP-specific (phosphodiesterase E3 dunce homolog, Drosophila)
Calculated Molecular Weight 809 aa, 91 kDa
Observed Molecular Weight 91-110 kDa, 66-84 kDa
GenBank Accession NumberBC036319
Gene Symbol PDE4D
Gene ID (NCBI) 5144
RRIDAB_2882372
Conjugate Unconjugated
Form Liquid
Purification MethodProtein G purification
UNIPROT IDQ08499
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.

Background Information

PDE4D(cAMP-specific 3',5'-cyclic phosphodiesterase 4D) is also known as DPDE3, PDE43 and belongs to the cyclic nucleotide phosphodiesterase family and PDE4 subfamily. PDE4D subtype may be of particular importance as an antidepressant target in that it is regulated by repeated treatment with both norepinephrine and serotonin reuptake inhibitors as well as by the PDE4 inhibitor rolipram (PMID:16730340). It has some isoforms and all the PDE4D isoforms are expressed in healthy adult human hippocampus and in the hippocampus from a patient with advanced Alzheimer disease (PMID:17353396). Bands of 90-110 kDa correspond to the long PDE4D isoforms, and bands of 66-84 kDa are the short PDE4D isoforms (PMID: 17215491).

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