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  • KD/KO Validated

PCSK5 Polyclonal antibody

PCSK5 Polyclonal Antibody for IHC, ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse and More (1)

Applications

IHC, IF, ELISA

Conjugate

Unconjugated

Cat no : 16470-1-AP

Synonyms

hPC6, PC5, PC6, PC6A, PCSK5, Proprotein convertase 5, Proprotein convertase 6, SPC6



Tested Applications

Positive IHC detected inhuman kidney tissue, human brain tissue, human skin tissue, human heart tissue, human testis tissue, human spleen tissue, mouse brain tissue
Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0

Recommended dilution

ApplicationDilution
Immunohistochemistry (IHC)IHC : 1:50-1:500
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

Product Information

16470-1-AP targets PCSK5 in IHC, IF, ELISA applications and shows reactivity with human, mouse samples.

Tested Reactivity human, mouse
Cited Reactivityhuman, rat
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen PCSK5 fusion protein Ag9552
Full Name proprotein convertase subtilisin/kexin type 5
Calculated Molecular Weight 102 kDa, 207 kDa
Observed Molecular Weight 210 kDa
GenBank Accession NumberBC012064
Gene Symbol PCSK5
Gene ID (NCBI) 5125
RRIDAB_2283381
Conjugate Unconjugated
Form Liquid
Purification MethodAntigen affinity purification
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. 20ul sizes contain 0.1% BSA.

Background Information

PC5 ,a mammalian kex2-like processing endoprotease, mediates posttranslational endoproteolytic processing for several integrin alpha subunits.It has been identified in rat and mouse endocrine and neuroendocrine tissues,and is encoded by multiple mRNAs that generate two splice variant isoforms referred to as PC5A (102KDa) and PC5B (207KDa) .PC5A is smaller than PC5B and it can be processed into two forms (117 kDa and 65 kDa) in neuronal cells(PMID:11457520).

Protocols

Product Specific Protocols
IHC protocol for PCSK5 antibody 16470-1-APDownload protocol
Standard Protocols
Click here to view our Standard Protocols

Publications

SpeciesApplicationTitle
rat

Mol Med Rep

MicroRNA‑338‑3p regulates age‑associated osteoporosis via targeting PCSK5.

Authors - Jie Tong
  • KD Validated
human

Biochem Biophys Rep

Secreted factors from adipose tissue-derived mesenchymal stem cells suppress oxygen/glucose deprivation-induced cardiomyocyte cell death via furin/PCSK-like enzyme activity.

Authors - Yuki Tachida
humanIHC

Mol Cell Biochem

PCSK5 downregulation promotes the inhibitory effect of andrographolide on glioblastoma through regulating STAT3

Authors - Huiyuan Gong
humanIF

Circ Heart Fail

Overexpression of ATP5F1A in Cardiomyocytes Promotes Cardiac Reverse Remodeling

Authors - Mengda Xu