Product Information
66674-1-PBS targets PARK2/Parkin in WB, IHC, IF/ICC, Indirect ELISA applications and shows reactivity with human, mouse samples.
Tested Reactivity | human, mouse |
Host / Isotype | Mouse / IgG2b |
Class | Monoclonal |
Type | Antibody |
Immunogen | PARK2/Parkin fusion protein Ag5179 Predict reactive species |
Full Name | Parkinson disease (autosomal recessive, juvenile) 2, parkin |
Calculated Molecular Weight | 52 kDa |
Observed Molecular Weight | 42-52 kDa |
GenBank Accession Number | BC022014 |
Gene Symbol | Parkin |
Gene ID (NCBI) | 5071 |
RRID | AB_2882028 |
Conjugate | Unconjugated |
Form | Liquid |
Purification Method | Protein A purification |
UNIPROT ID | O60260 |
Storage Buffer | PBS Only |
Storage Conditions | Store at -80°C. |
Background Information
Parkin, a RING-type E3 ubiquitin-protein ligase, is involved in the ubiquitination pathway and contributes to protection from neurotoxicity induced by unfolded protein stresses. Its ubiquitin-protein ligase activity promotes the degradation of a viariety of proteins including itself. Mutations in Parkin are implicated in the pathogenesis of autosomal recessive familial Parkinson's disease. It has 8 isoforms produced by alternative splicing.