P glycoprotein Recombinant antibody, PBS Only

P glycoprotein Uni-rAb^TM Recombinant Antibody for WB, Indirect ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

WB, Indirect ELISA

Conjugate

Unconjugated

CloneNo.

241512A1

Cat no : 84295-3-PBS

Synonyms

ABCB1, 241512A1, EC:7.6.2.2, EC:7.6.2.1, ATP-dependent translocase ABCB1

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Validation Data Gallery

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  WB analysis using 84295-3-RR (same clone as 84295-3-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 84295-3-RR (P glycoprotein antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 84295-3-PBS in a different storage buffer formulation.

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Product Information

84295-3-PBS targets P glycoprotein in WB, Indirect ELISA applications and shows reactivity with human samples.

• Tested Reactivity: human
• Host / Isotype: Rabbit / IgG
• Class: Recombinant
• Type: Antibody
• Immunogen: Recombinant protein
• Full Name: ATP-binding cassette, sub-family B (MDR/TAP), member 1
• Calculated Molecular Weight: 1280 aa, 142 kDa
• Observed Molecular Weight: 130-150 kDa
• GenBank Accession Number: BC130424
• Gene Symbol: P glycoprotein
• Gene ID (NCBI): 5243
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Protein A purfication
• Storage Buffer: PBS Only
• Storage Conditions: Store at -80°C.

Background Information

ABCB1 (also known as P-gp/ P-glycoprotein, MDR1/multidrug-resistance 1) is a plasma membrane protein first discovered in multidrug resistant tumor cells. ABCB1 can extrude a large number of medically relevant compounds from cells and causes drug resistance. ABCB1 is expressed in a variety of human cancers as well as normal tissues including brain, and placenta. Overexpression of ABCB1 correlates with a negative prognosis in several types of cancer.