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  • KD/KO Validated

OLR1 Polyclonal antibody

OLR1 Polyclonal Antibody for WB, IP, FC, IHC, ELISA

Host / Isotype

Rabbit / IgG


human, mouse





Cat no : 11837-1-AP


CLEC8A, hLOX 1, Lectin like oxLDL receptor 1, LOX 1, LOX1, OLR1, Ox LDL receptor 1, SCARE1

Tested Applications

Positive WB detected inbEnd.3 cells, human liver tissue
Positive IP detected inL02 cells
Positive IHC detected inhuman heart tissue
Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0
Positive FC detected inHUVEC cells

Recommended dilution

Western Blot (WB)WB : 1:1000-1:6000
Immunoprecipitation (IP)IP : 0.5-4.0 ug for 1.0-3.0 mg of total protein lysate
Immunohistochemistry (IHC)IHC : 1:50-1:500
Flow Cytometry (FC)FC : 0.20 ug per 10^6 cells in a 100 µl suspension
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

Product Information

11837-1-AP targets OLR1 in WB, IP, IF, FC, IHC, CoIP, ELISA applications and shows reactivity with human, mouse samples.

Tested Reactivity human, mouse
Cited Reactivityhuman, mouse
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen OLR1 fusion protein Ag2437
Full Name oxidized low density lipoprotein (lectin-like) receptor 1
Calculated Molecular Weight 273 aa, 31 kDa
Observed Molecular Weight 50-55 kDa
GenBank Accession NumberBC022295
Gene Symbol OLR1
Gene ID (NCBI) 4973
Conjugate Unconjugated
Form Liquid
Purification MethodAntigen affinity purification
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. 20ul sizes contain 0.1% BSA.

Background Information

OLR1/LOX-1 acts as a receptor, in the form of homodimer, that mediates the recognition, internalization, and degradation of oxidatively modified low density lipoprotein (oxLDL) (PMID: 9052782, 15695803). ORL1 is predominantly expressed in endothelial cells and vascular-rich organs such as the placenta, lung, liver, and brain (PMID: 9828121). OLR1 is a protein containing 273 amino acids with a calculated molecular mass of 31 kDa but an apparent molecular mass of 50 kDa, which may result from the glycosylation of four potential N-linked glycosylation sites located at the C-terminal domain (PMID: 9052782).


Product Specific Protocols
WB protocol for OLR1 antibody 11837-1-APDownload protocol
IHC protocol for OLR1 antibody 11837-1-APDownload protocol
IP protocol for OLR1 antibody 11837-1-APDownload protocol
Standard Protocols
Click here to view our Standard Protocols



Free Radic Biol Med

Up-regulation of thioredoxin system by puerarin inhibits lipid uptake in macrophages

Authors - Wenchao Li,

Cancer Lett

Up-regulation of OLR1 expression by TBC1D3 through activation of TNFα/NF-κB pathway promotes the migration of human breast cancer cells.

Authors - Bei Wang
  • KD Validated


Deacetylation of Caveolin-1 by Sirt6 induces autophagy and retards high glucose-stimulated LDL transcytosis and atherosclerosis formation.

Authors - Ying Zhao

Sci Rep

Lectin-like oxidized low-density lipoprotein receptor-1 facilitates metastasis of gastric cancer through driving epithelial-mesenchymal transition and PI3K/Akt/GSK3β activation.

Authors - Can Li
  • KD Validated

Int J Cancer

The oxidized-LDL/LOX-1 axis in tumor endothelial cells enhances metastasis by recruiting neutrophils and cancer cells.

Authors - Takuya Tsumita

Mol Cancer Res

OLR1 Promotes Pancreatic Cancer Metastasis via Increased c-Myc Expression and Transcription of HMGA2.

Authors - Gang Yang
  • KD Validated