NR2E3 Polyclonal antibody, PBS Only

• Featured Product
• KD/KO Validated

NR2E3 Polyclonal Antibody for WB, IHC, IF/ICC, Indirect ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse, rat, pig

Applications

WB, IHC, IF/ICC, Indirect ELISA

Conjugate

Unconjugated

Cat no : 14246-1-PBS

Synonyms

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Validation Data Gallery

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  WB analysis using 14246-1-AP (same clone as 14246-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 14246-1-AP (NR2E3 antibody) at dilution of 1:6000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 14246-1-PBS in a different storage buffer formulation.

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  WB analysis of HepG2 using 14246-1-AP (same clone as 14246-1-PBS)

  HepG2 cells were subjected to SDS PAGE followed by western blot with 14246-1-AP (NR2E3 Antibody) at dilution of 1:600 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 14246-1-PBS in a different storage buffer formulation.

• 

  WB analysis of HepG2 using 14246-1-AP (same clone as 14246-1-PBS)

  HepG2 cells were subjected to SDS PAGE followed by western blot with 14246-1-AP (NR2E3 Antibody) at dilution of 1:600 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 14246-1-PBS in a different storage buffer formulation.

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  WB analysis of Y79 using 14246-1-AP (same clone as 14246-1-PBS)

  Y79 cells were subjected to SDS PAGE followed by western blot with 14246-1-AP (NR2E3 antibody) at dilution of 1:300 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 14246-1-PBS in a different storage buffer formulation.

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  IHC staining of human prostate cancer using 14246-1-AP (same clone as 14246-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human prostate cancer using 14246-1-AP (NR2E3 antibody) at dilution of 1:100 (under 10x lens). This data was developed using the same antibody clone with 14246-1-PBS in a different storage buffer formulation.

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  IHC staining of human prostate cancer using 14246-1-AP (same clone as 14246-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human prostate cancer using 14246-1-AP (NR2E3 antibody) at dilution of 1:100 (under 40x lens). This data was developed using the same antibody clone with 14246-1-PBS in a different storage buffer formulation.

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  IF Staining of photoreceptor progenitor cells using 14246-1-AP (same clone as 14246-1-PBS)

  IF result of NR2E3 antibody (14246-1-AP, 1:50) with human photoreceptor progenitors cells. This data was developed using the same antibody clone with 14246-1-PBS in a different storage buffer formulation.

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Product Information

14246-1-PBS targets NR2E3 in WB, IHC, IF/ICC, Indirect ELISA applications and shows reactivity with human, mouse, rat, pig samples.

• Tested Reactivity: human, mouse, rat, pig
• Host / Isotype: Rabbit / IgG
• Class: Polyclonal
• Type: Antibody
• Immunogen: NR2E3 fusion protein Ag5503
• Full Name: nuclear receptor subfamily 2, group E, member 3
• Calculated Molecular Weight: 45 kDa
• Observed Molecular Weight: 43-45 kDa
• GenBank Accession Number: BC041421
• Gene Symbol: NR2E3
• Gene ID (NCBI): 10002
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Antigen affinity purification
• Storage Buffer: PBS Only
• Storage Conditions: Store at -80°C.

Background Information

NR2E3, also known as PNR, encodes a retinal nuclear receptor that is a ligand-dependent transcription factor. This protein is part of a large family of nuclear receptor transcription factors involved in signaling pathways. NR2E3 influences the development of photoreceptors and their differentiation into rod and cone types, and acts as a ranscriptional factor that is an activator of rod development and repressor of cone development [PMID:20725840]. It binds the promoter region of a number of rod- and cone-specific genes, including rhodopsin, M- and S-opsin and rod-specific phosphodiesterase beta subunit. [PMID:15689355]