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NPTX2 Monoclonal antibody, PBS Only

NPTX2 Monoclonal Antibody for WB, Indirect ELISA

Host / Isotype

Mouse / IgG1

Reactivity

Human, mouse, rat, pig, rabbit

Applications

WB, Indirect ELISA

Conjugate

Unconjugated

CloneNo.

2H8D8

Cat no : 68709-1-PBS

Synonyms

NARP, Neuronal pentraxin 2, neuronal pentraxin II, NPTX2

Validation Data Gallery

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  • Western Blot (WB) analysis of various lysates using NPTX2 Monoclonal antibody (68709-1-Ig)

    WB analysis using 68709-1-Ig (same clone as 68709-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 68709-1-Ig (NPTX2 antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 68709-1-PBS in a different storage buffer formulation.

Product Information

68709-1-PBS targets NPTX2 in WB, Indirect ELISA applications and shows reactivity with Human, mouse, rat, pig, rabbit samples.

Tested Reactivity Human, mouse, rat, pig, rabbit
Host / Isotype Mouse / IgG1
Class Monoclonal
Type Antibody
Immunogen NPTX2 fusion protein Ag33808
Full Name neuronal pentraxin II
Calculated Molecular Weight 47 kDa
Observed Molecular Weight50-55 kDa
GenBank Accession NumberBC009924
Gene Symbol NPTX2
Gene ID (NCBI) 4885
Conjugate Unconjugated
Form Liquid
Purification MethodProtein G purification
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.

Background Information

Neuronal pentraxins constitute a family of proteins that are homologous to C-reactive protein (CRP) and serum amyloid P component (SAP), including NPTX1, NPTX2, and the neuronal pentraxin receptor (NPTXR). NPTX2, also known as NARP (neuronal activity-regulated pentaxin), is a secreted protein involved in excitatory synapse formation. It also plays a role in the clustering of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type glutamate receptors at established synapses, resulting in non-apoptotic cell death of dopaminergic nerve cells. NPTX2 is highly up-regulated in Parkinson's disease (PD), suggesting it may be involved in the pathology of PD. (PMID: 12895424; 17987278; 10748068)