NPHP5/IQCB1 Monoclonal antibody, PBS Only

NPHP5/IQCB1 Monoclonal Antibody for WB, Indirect ELISA

Host / Isotype

Mouse / IgG2a

Reactivity

Human

Applications

WB, Indirect ELISA

Conjugate

Unconjugated

CloneNo.

2A9F4

Cat no : 68404-1-PBS

Synonyms

IQ motif containing B1, IQCB1, KIAA0036, Nephrocystin 5, PIQ, SLSN5

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Validation Data Gallery

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  WB analysis using 68404-1-Ig (same clone as 68404-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 68404-1-Ig (NPHP5,IQCB1 antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 68404-1-PBS in a different storage buffer formulation.

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Product Information

68404-1-PBS targets NPHP5/IQCB1 in WB, Indirect ELISA applications and shows reactivity with Human samples.

• Tested Reactivity: Human
• Host / Isotype: Mouse / IgG2a
• Class: Monoclonal
• Type: Antibody
• Immunogen: NPHP5/IQCB1 fusion protein Ag8203
• Full Name: IQ motif containing B1
• Calculated Molecular Weight: 598 aa, 69 kDa
• Observed Molecular Weight: 69 kDa
• GenBank Accession Number: BC005806
• Gene Symbol: IQCB1
• Gene ID (NCBI): 9657
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Protein A purification
• Storage Buffer: PBS Only
• Storage Conditions: Store at -80°C.

Background Information

IQCB1, also known as NPHP5, is a nephrocystin protein that interacts with calmodulin and the retinitis pigmentosa GTPase regulator protein. It has a central coiled-coil region and two calmodulin-binding IQ domains. Localized to the primary cilia of renal epithelial cells and connecting cilia of photoreceptor cells, IQCB1 is thought to play a role in ciliary function. Mutations in this gene result in Senior-Loken syndrome type 5, a juvenile disorder characterized by defects in the waste filtering system of the kidney, as well as retinal degradation.