NLRP12 Polyclonal antibody, PBS Only

NLRP12 Polyclonal Antibody for WB, IP, Indirect ELISA
Cat No. 30998-1-PBS

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse, rat

Applications

WB, IP, Indirect ELISA

Formulation:  PBS Only
PBS and Azide
PBS Only
Conjugate:  Unconjugated
Size/Concentration: 

-/ -

Freight/Packing: -

Quantity

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Product Information

30998-1-PBS targets NLRP12 in WB, IP, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.

Tested Reactivity human, mouse, rat
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen NLRP12 fusion protein Ag34281 Predict reactive species
Full Name NLR family, pyrin domain containing 12
Calculated Molecular Weight 1061 aa, 120 kDa
Observed Molecular Weight 95-110 kDa
GenBank Accession NumberBC028069
Gene Symbol NLRP12
Gene ID (NCBI) 91662
Conjugate Unconjugated
Form Liquid
Purification MethodAntigen affinity Purification
UNIPROT IDP59046
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.

Background Information

NACHT, LRR and PYD domains-containing protein 12 (NLRP12) is also named as Monarch-1, NALP12, PYPAF7 and RNO. NLRP12 is as an essential cytosolic sensor for heme plus PAMPs-mediated PANoptosis, inflammation, and pathology (PMID: 37267949). NLRP12 drives inflammasome and PANoptosome activation, cell death, and inflammation in response to heme plus PAMPs or TNF. TLR2/4-mediated signaling through IRF1 induced Nlrp12 expression, which led to inflammasome formation to induce maturation of IL-1β and IL-18 (PMID: 37267949). NLRP12, a pyrin-containing NLR protein, is a negative regulator of innate immune activation and type I interferon (IFN-I) production (PMID: 36719379).

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