NKp46/NCR1 Recombinant antibody

• 

  IF Staining of NK-92 using 85021-4-RR

  Immunofluorescent analysis of (4% PFA) fixed NK-92 cells using NKp46/NCR1/CD335 antibody (85021-4-RR, Clone: 242549C5 ) at dilution of 1:400 and CoraLite®488-Conjugated Goat Anti-Rabbit IgG(H+L) (SA00013-2).

NKp46/NCR1 {ptg:Brand} Recombinant Antibody for IF/ICC, ELISA

Cat No. 85021-4-RR

Clone No.242549C5

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

IF/ICC, ELISA

Synonyms

NCR 1, Natural killer cell p46-related protein, LY94, hNKp46, CD335

---

Tested Applications

• Positive IF/ICC detected in: NK-92 cells

Recommended dilution

• Immunofluorescence (IF)/ICC: IF/ICC : 1:200-1:800

It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Sample-dependent, Check data in validation data gallery.

Product Information

85021-4-RR targets NKp46/NCR1 in IF/ICC, ELISA applications and shows reactivity with human samples.

• Tested Reactivity: human
• Host / Isotype: Rabbit / IgG
• Class: Recombinant
• Type: Antibody
• Immunogen: Recombinant protein
• Full Name: natural cytotoxicity triggering receptor 1
• Calculated Molecular Weight: 34kDa
• Gene Symbol: NCR1
• Gene ID (NCBI): 9437
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Protein A purification
• UNIPROT ID: O76036-1
• Storage Buffer: PBS with 0.02% sodium azide and 50% glycerol , pH 7.3
• Storage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20^oC storage. 20ul sizes contain 0.1% BSA.

Background Information

NKp46, also known as natural cytotoxicity triggering receptor 1 (NCR1), is a type I transmembrane protein belonging to the immunoglobulin superfamily. NKp46 is a key activating receptor expressed on natural killer (NK) cells. It plays a key role in the innate immune response by recognizing and binding to viral hemagglutinins and other ligands on infected or tumor cells. NKp46 mediates cytotoxicity and cytokine production upon engagement with its ligands, contributing to the elimination of infected or malignant cells. Its expression and function are tightly regulated, and dysregulation of NKp46 has been implicated in various diseases, including viral infections, cancer, and autoimmune disorders. (PMID: 11234016; 29329948; 9730896; 9314561).