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NDP Polyclonal antibody, PBS Only

NDP Polyclonal Antibody for WB, Indirect ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse

Applications

WB, Indirect ELISA

Conjugate

Unconjugated

Cat no : 15380-1-PBS

Synonyms

Validation Data Gallery

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  • Western Blot (WB) analysis of mouse testis tissue using NDP Polyclonal antibody (15380-1-AP)

    WB analysis of mouse testis using 15380-1-AP (same clone as 15380-1-PBS)

    mouse testis tissue were subjected to SDS PAGE followed by western blot with 15380-1-AP (NDP antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 15380-1-PBS in a different storage buffer formulation.

  • Western Blot (WB) analysis of mouse eye tissue using NDP Polyclonal antibody (15380-1-AP)

    WB analysis of mouse eye using 15380-1-AP (same clone as 15380-1-PBS)

    mouse eye tissue were subjected to SDS PAGE followed by western blot with 15380-1-AP (NDP antibody) at dilution of 1:600 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 15380-1-PBS in a different storage buffer formulation.

Product Information

15380-1-PBS targets NDP in WB, Indirect ELISA applications and shows reactivity with human, mouse samples.

Tested Reactivity human, mouse
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen NDP fusion protein Ag4066
Full Name Norrie disease (pseudoglioma)
Calculated Molecular Weight 15 kDa
Observed Molecular Weight 50-60 kDa
GenBank Accession NumberBC029901
Gene Symbol NDP
Gene ID (NCBI) 4693
Conjugate Unconjugated
Form Liquid
Purification MethodAntigen affinity purification
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.

Background Information

NDP, also named as EVR2, ND and Norrin, is a secreted regulatory protein that remains tightly associated with the extracellular matrix. Mutations in the NDP gene are associated with the Norrie disease. Signaling induced by the protein NDP regulates vascular development of vertebrate retina and controls important blood vessels in the ear. It binds with high affinity to Frizzled 4, and Frizzled 4 knockout mice exhibit abnormal vascular development of the retina. This antibody detects 11-15 kDa (monomer) and 48 kDa (polymers, refer: 25692504).