NDP Polyclonal antibody, PBS Only

• 

  WB analysis of mouse testis using 15380-1-AP (same clone as 15380-1-PBS)

  mouse testis tissue were subjected to SDS PAGE followed by western blot with 15380-1-AP (NDP antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 15380-1-PBS in a different storage buffer formulation.

• 

  WB analysis of mouse eye using 15380-1-AP (same clone as 15380-1-PBS)

  mouse eye tissue were subjected to SDS PAGE followed by western blot with 15380-1-AP (NDP antibody) at dilution of 1:600 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 15380-1-PBS in a different storage buffer formulation.

NDP Polyclonal Antibody for WB, Indirect ELISA

Cat No. 15380-1-PBS

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse

Applications

WB, Indirect ELISA

Synonyms

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Product Information

15380-1-PBS targets NDP in WB, Indirect ELISA applications and shows reactivity with human, mouse samples.

• Tested Reactivity: human, mouse
• Host / Isotype: Rabbit / IgG
• Class: Polyclonal
• Type: Antibody
• Immunogen: NDP fusion protein Ag4066
• Full Name: Norrie disease (pseudoglioma)
• Calculated Molecular Weight: 15 kDa
• Observed Molecular Weight: 50-60 kDa
• GenBank Accession Number: BC029901
• Gene Symbol: NDP
• Gene ID (NCBI): 4693
• RRID: AB_2878133
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Antigen affinity purification
• UNIPROT ID: Q00604
• Storage Buffer: PBS only , pH 7.3
• Storage Conditions: Store at -80°C.

Background Information

NDP, also named as EVR2, ND and Norrin, is a secreted regulatory protein that remains tightly associated with the extracellular matrix. Mutations in the NDP gene are associated with the Norrie disease. Signaling induced by the protein NDP regulates vascular development of vertebrate retina and controls important blood vessels in the ear. It binds with high affinity to Frizzled 4, and Frizzled 4 knockout mice exhibit abnormal vascular development of the retina. This antibody detects 11-15 kDa (monomer) and 48 kDa (polymers, refer: 25692504).