NCOR2 Polyclonal antibody

NCOR2 Polyclonal Antibody for ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse, rat

Applications

WB, IF, CoIP, ELISA

Conjugate

Unconjugated

Publications

3

Cat no : 20017-1-AP

Synonyms

CTG repeat protein 26, CTG26, N CoR2, NCOR2, Nuclear receptor corepressor 2, SMAP270, SMRT, SMRTE, SMRTE tau, T3 receptor associating factor, TNRC14, TRAC, TRAC 1, TRAC1

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Validation Data Gallery

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  WB analysis of HeLa using 20017-1-AP

  HeLa cells were subjected to SDS PAGE followed by western blot with 20017-1-AP (NCOR2 antibody) at dilution of 1:200 incubated at room temperature for 1.5 hours.

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  WB analysis of Jurkat using 20017-1-AP

  Jurkat cells were subjected to SDS PAGE followed by western blot with 20017-1-AP (NCOR2 antibody) at dilution of 1:300 incubated at room temperature for 1.5 hours.

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Published Applications

• WB: See 1 publications below
• IF: See 1 publications below
• CoIP: See 1 publications below

Product Information

20017-1-AP targets NCOR2 in WB, IF, CoIP, ELISA applications and shows reactivity with human, mouse, rat samples.

• Tested Reactivity: human, mouse, rat
• Cited Reactivity: human
• Host / Isotype: Rabbit / IgG
• Class: Polyclonal
• Type: Antibody
• Immunogen: Peptide
• Full Name: nuclear receptor co-repressor 2
• Calculated Molecular Weight: 275 kDa
• GenBank Accession Number: NM_006312
• Gene Symbol: NCOR2
• Gene ID (NCBI): 9612
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Antigen affinity purification
• Storage Buffer: PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
• Storage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20^oC storage. 20ul sizes contain 0.1% BSA.

Background Information

NCOR2, also named as CTG26, SMRT, SMRTE, SMRTE-tau, TNRC14, TRAC-1, TRAC1 and SMAP270, belongs to the N-CoR nuclear receptor corepressors family. NCOR2 mediates the transcriptional repression activity of some nuclear receptors by promoting chromatin condensation, thus preventing access of the basal transcription. Isoform 1 and isoform 5 have different affinities for different nuclear receptors. The antibody recognizes all the isoforms of NCOR2. An about 180 KDa was also reported(PMID: 23081895).

Publications

Species	Application	Title
human	CoIP	Adv Sci (Weinh); Transcriptional Repression of Aerobic Glycolysis by OVOL2 in Breast Cancer.; Authors - Shaliu Luo
human	WB	Cancer Sci; LncRNA MIR22HG inhibits growth, migration and invasion through regulating the miR-10a-5p/NCOR2 axis in hepatocellular carcinoma cells.; Authors - Yangjun Wu
	IF	Front Pharmacol; Analysis of Effect of Schisandra in the Treatment of Myocardial Infarction Based on Three-Mode Gene Ontology Network.; Authors - Siyao Hu