MS4A7 Polyclonal antibody

MS4A7 Polyclonal Antibody for WB, ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse

Applications

WB, ELISA

Conjugate

Unconjugated

Cat no : 11864-1-AP

Synonyms

4SPAN2, CD20 antigen like 4, CD20L4, CFFM4, MS4A7, MS4A8

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Validation Data Gallery

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  WB analysis using 11864-1-AP

  Various lysates were subjected to SDS PAGE followed by western blot with 11864-1-AP (MS4A7 antibody) at dilution of 1:600 incubated at room temperature for 1.5 hours.

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Tested Applications

• Positive WB detected in: BV-2 cells, K-562 cells

Recommended dilution

• Western Blot (WB): WB : 1:500-1:1000

It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Sample-dependent, Check data in validation data gallery.

Product Information

11864-1-AP targets MS4A7 in WB, ELISA applications and shows reactivity with human, mouse samples.

• Tested Reactivity: human, mouse
• Host / Isotype: Rabbit / IgG
• Class: Polyclonal
• Type: Antibody
• Immunogen: MS4A7 fusion protein Ag2442
• Full Name: membrane-spanning 4-domains, subfamily A, member 7
• Calculated Molecular Weight: 240 aa, 26 kDa
• Observed Molecular Weight: 26 kDa
• GenBank Accession Number: BC020673
• Gene Symbol: MS4A7
• Gene ID (NCBI): 58475
• RRID: AB_2144674
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Antigen affinity purification
• Storage Buffer: PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
• Storage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20^oC storage. 20ul sizes contain 0.1% BSA.

Background Information

The human MS4A family currently includes 18 members, and these proteins have four putative transmembrane domains (tetraspan) and several protein kinase C (PKC) phosphorylation sites. Membrane-spanning 4-domains a7 (MS4A7) is a member of the MS4A family. It is expressed by myeloid cells. MS4A7 can act as a NAM-specific pathogenic factor that exacerbates metabolic dysfunction-associated steatohepatitis (MASH) progression in mice (PMID: 38478630). There are two isoforms of MS4A7 protein, with molecular weights of 26.14 kDa and 21.41 kDa respectively.