MRE11A Monoclonal antibody, PBS Only

MRE11A Monoclonal Antibody for WB, Indirect ELISA
Cat No. 67570-1-PBS
Clone No.1B12B2

Host / Isotype

Mouse / IgG1

Reactivity

Human, Mouse, Rat

Applications

WB, Indirect ELISA

ATLD, HNGS1, MRE11, MRE11 homolog 1, MRE11 homolog A, MRE11A, MRE11B

Formulation:  PBS Only
PBS and Azide
PBS Only
Conjugate:  Unconjugated
Size/Concentration: 

-/ -

Freight/Packing: -

Quantity

Please visit your regions distributor:


Product Information

67570-1-PBS targets MRE11A in WB, Indirect ELISA applications and shows reactivity with Human, Mouse, Rat samples.

Tested Reactivity Human, Mouse, Rat
Host / Isotype Mouse / IgG1
Class Monoclonal
Type Antibody
Immunogen MRE11A fusion protein Ag28847 Predict reactive species
Full Name MRE11 meiotic recombination 11 homolog A (S. cerevisiae)
Observed Molecular Weight 81 kDa
GenBank Accession NumberBC063458
Gene Symbol MRE11A
Gene ID (NCBI) 4361
RRIDAB_2882784
Conjugate Unconjugated
Form Liquid
Purification MethodProtein G purification
UNIPROT IDP49959
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.

Background Information

Mre11 (meiotic recombination 11), also named as Mre11A, is a component of the MRN( MRE11/RAD50/NBS1) complex which is a versatile complex, playing a key role in the sensing, processing, and repair of DSBs. MRE11 possesses both endonuclease and 3'-5' exonuclease activity. It contains two DNA-binding domains (DBDs), enabling it to bind both single-stranded DNA (ssDNA) and double-stranded DNA (dsDNA). After DSBs, MRE11 is loaded onto DSBs sites and cleaves DNA by cooperating with CtIP (CtBP [C terminal binding protein] interacting protein) to initiate end resection. It's reported that MRE11 is over-expressed in breast cancers. (PMID:38128537; 22914783)

Loading...