MPP8 Recombinant antibody, PBS Only

MPP8 Uni-rAbTM Recombinant Antibody for WB, Indirect ELISA
Cat No. 84719-4-PBS
Clone No.242205B5

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

WB, Indirect ELISA

MPHOSPH8, Two hybrid-associated protein 3 with RanBPM, Twa3, M-phase phosphoprotein 8, HSMPP8

Formulation:  PBS Only
PBS and Azide
PBS Only
Conjugate:  Unconjugated
Size/Concentration: 

-/ -

Freight/Packing: -

Quantity

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Product Information

84719-4-PBS targets MPP8 in WB, Indirect ELISA applications and shows reactivity with human samples.

Tested Reactivity human
Host / Isotype Rabbit / IgG
Class Recombinant
Type Antibody
Immunogen MPP8 fusion protein Ag10268 Predict reactive species
Full Name M-phase phosphoprotein 8
Calculated Molecular Weight 860 aa, 97 kDa
Observed Molecular Weight 97-105 kDa
GenBank Accession NumberBC003542
Gene Symbol MPP8
Gene ID (NCBI) 54737
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purfication
UNIPROT IDQ99549
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.

Background Information

The M-phase phosphoprotein 8 (MPP8) was firstly identified to coimmunoprecipitate with the RanBPM-comprised large protein complex [PMID:19956676]. It also binds to methylated H3K9 and recruited the H3K9 methyltransferases GLP and ESET, as well as DNA methyltransferase 3A (DNMT3A) to the promoter of the E-cadherin gene, a key regulator of tumor cell growth and epithelial-to-mesenchymal transition (EMT) [PMID:18726070]. This binding event of MPP8-H3K9me modulates the expression of E-cadherin, a key regulator of cell-cell adhesion with implications in embryonic development, tissue morphogenesis and homeostasis , together with H3K9 methyltransferases GLP and ESET and DNA methyltransferase 3a (Dnmt3a)

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