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MIP-1 Alpha/CCL3 Polyclonal antibody, PBS Only

MIP-1 Alpha/CCL3 Polyclonal Antibody for WB, Indirect ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

WB, Indirect ELISA

Conjugate

Unconjugated

Cat no : 16748-1-PBS

Synonyms

Validation Data Gallery

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  • Western Blot (WB) analysis of various lysates using MIP-1 Alpha/CCL3 Polyclonal antibody (16748-1-AP)

    WB analysis using 16748-1-AP (same clone as 16748-1-PBS)

    PMA, LPS and Brefeldin A treated THP-1 cells were subjected to SDS PAGE followed by western blot with 16748-1-AP (MIP-1 Alpha/CCL3 antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 16748-1-PBS in a different storage buffer formulation.

Product Information

16748-1-PBS targets MIP-1 Alpha/CCL3 in WB, Indirect ELISA applications and shows reactivity with human samples.

Tested Reactivity human
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen MIP-1 Alpha/CCL3 fusion protein Ag10183
Full Name chemokine (C-C motif) ligand 3
Calculated Molecular Weight 92 aa, 10 kDa
GenBank Accession NumberBC071834
Gene Symbol CCL3/MIP-1 alpha
Gene ID (NCBI) 6348
Conjugate Unconjugated
Form Liquid
Purification MethodAntigen affinity purification
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.

Background Information

Chemokine (C-C motif) ligand 3 (CCL3), also known as MIP-1α, belongs to the family of chemokines. CCL3 has been found in the central nervous system and its cognate receptors, CCR1 and CCR5, have been reported to be expressed by astrocytes, microglia and neurons. CCL3 and its receptors, CCR1 and CCR5, also contribute to the development of bone disease in multiple myeloma by supporting tumor growth and regulating osteoclast differentiation. CCL3 is also associated with the regulation of cell growth, angiogenesis, and metastasis of different tumors such as melanoma, renal cell carcinoma, and colorectal cancer. Moreover, CCL3 enhances cell migration and metastasis by up-regulating matrix metalloproteinase-2 (MMP)-2 expression in chondrosarcoma cells.