MICA/MICB Recombinant antibody, PBS Only

MICA/MICB Uni-rAb^TM Recombinant Antibody for Indirect ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

Indirect ELISA

Conjugate

Unconjugated

CloneNo.

242004F3

Cat no : 84850-4-PBS

Synonyms

MICA, MIC-A, MIC A, 242004F3

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Validation Data Gallery

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  WB analysis using 84850-4-RR (same clone as 84850-4-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 84850-4-RR (MICA antibody) at dilution of 1:3000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 84850-4-PBS in a different storage buffer formulation.

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Product Information

84850-4-PBS targets MICA/MICB in Indirect ELISA applications and shows reactivity with human samples.

• Tested Reactivity: human
• Host / Isotype: Rabbit / IgG
• Class: Recombinant
• Type: Antibody
• Immunogen: Recombinant protein
• Full Name: MHC class I polypeptide-related sequence A
• Calculated Molecular Weight: 383 aa, 43 kDa
• Observed Molecular Weight: 38 kDa, 40 kDa
• GenBank Accession Number: BC016929
• Gene Symbol: MICA
• Gene ID (NCBI): 100507436
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Protein A purfication
• Storage Buffer: PBS Only
• Storage Conditions: Store at -80°C.

Background Information

Human MHC class I chain-related genes located within the HLA class I region of chromosome 6 encode MHC class I chain-related A and B (MICA and MICB) (PMID: 11429322). MICA and MICB are stress-inducible surface molecules that are not associated with β2-microglobulin and do not present peptides (PMID: 9497295). They are expressed in intestinal epithelium and many epithelial tumors (PMID: 10359807). MICA and MICB are ligands for NKG2D which is an activating receptor that is expressed on most natural killer (NK) cells, CD8 αβ T cells, and γδ T cells (PMID: 10426993; 11491531). This antibody recognizes both MICA and MICB.