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MCRS1 Monoclonal antibody, PBS Only

MCRS1 Monoclonal Antibody for WB, Indirect ELISA

Host / Isotype

Mouse / IgG2a

Reactivity

human, mouse, rat

Applications

WB, Indirect ELISA

Conjugate

Unconjugated

CloneNo.

2H10E10

Cat no : 60215-1-PBS

Synonyms

58 kDa microspherule protein, ICP22BP, INO80 complex subunit J, INO80Q, MCRS1, MCRS2, microspherule protein 1, MSP58, P78

Validation Data Gallery

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  • Western Blot (WB) analysis of ROS1728 cells using MCRS1 Monoclonal antibody (60215-1-Ig)

    WB analysis of ROS1728 using 60215-1-Ig (same clone as 60215-1-PBS)

    ROS1728 cells were subjected to SDS PAGE followed by western blot with 60215-1-Ig (MCRS1 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 60215-1-PBS in a different storage buffer formulation.

  • Western Blot (WB) analysis of U2OS cells using MCRS1 Monoclonal antibody (60215-1-Ig)

    WB analysis of U2OS using 60215-1-Ig (same clone as 60215-1-PBS)

    U2OS cells were subjected to SDS PAGE followed by western blot with 60215-1-Ig (MCRS1 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 60215-1-PBS in a different storage buffer formulation.

Product Information

60215-1-PBS targets MCRS1 in WB, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.

Tested Reactivity human, mouse, rat
Host / Isotype Mouse / IgG2a
Class Monoclonal
Type Antibody
Immunogen MCRS1 fusion protein Ag1904
Full Name microspherule protein 1
Calculated Molecular Weight 51 kDa
Observed Molecular Weight 55+110 kDa
GenBank Accession NumberBC011794
Gene Symbol MCRS1
Gene ID (NCBI) 10445
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purification
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.

Background Information

MCRS1, also named INO80Q, MSP58 or p78, is a nucleolar protein expressed in the very early S phase. It modulates the transcription repressor activity of DAXX by recruiting it to the nucleolus. MCRS1 is also present on polyribosomes of synaptoneurosome as a novel RNA-binding protein to activate the rRNA transcription. The forkhead-associated domain of MCRS1 is involved in association with centrosomal protein Nde1, comprising a component of the centrosome and taking an essential role in viability. Its isoform MCRS2 might be a linker between telomere maintenance and cell-cycle regulation by interacting with LPTS/PinX1, a telomerase-inhibitory protein. MCRS1 is detected by Western blot as a highly modified protein at 78 kDa and minor bands at about 62 and 55 kDa.