Product Information
23263-1-PBS targets MAML3 in WB, IF/ICC, Indirect ELISA applications and shows reactivity with human samples.
Tested Reactivity | human |
Host / Isotype | Rabbit / IgG |
Class | Polyclonal |
Type | Antibody |
Immunogen | MAML3 fusion protein Ag19788 Predict reactive species |
Full Name | mastermind-like 3 (Drosophila) |
Calculated Molecular Weight | 1133 aa, 122 kDa |
Observed Molecular Weight | 122 kDa |
GenBank Accession Number | BC137131 |
Gene Symbol | MAML3 |
Gene ID (NCBI) | 55534 |
RRID | AB_2879242 |
Conjugate | Unconjugated |
Form | Liquid |
Purification Method | Antigen affinity purification |
UNIPROT ID | Q96JK9 |
Storage Buffer | PBS Only |
Storage Conditions | Store at -80°C. |
Background Information
The three MAML genes are widely expressed in adult tissues but exhibit distinct expression patterns in mouse early spinal cord development. All MAML proteins localize to nuclear bodies, share a conserved basic domain in their N termini that binds to the ankyrin repeat domain of Notch, and contain a transcriptional activation domain in their C termini. MAML3 acts as a transcriptional coactivator for NOTCH proteins and has been shown to amplify NOTCH-induced transcription of HES1.