Product Information
12683-1-PBS targets MAD2L2 in WB, IHC, IP, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.
Tested Reactivity | human, mouse, rat |
Host / Isotype | Rabbit / IgG |
Class | Polyclonal |
Type | Antibody |
Immunogen | MAD2L2 fusion protein Ag3373 Predict reactive species |
Full Name | MAD2 mitotic arrest deficient-like 2 (yeast) |
Calculated Molecular Weight | 211 aa, 24 kDa |
Observed Molecular Weight | 24 kDa |
GenBank Accession Number | BC015244 |
Gene Symbol | MAD2L2 |
Gene ID (NCBI) | 10459 |
RRID | AB_2139530 |
Conjugate | Unconjugated |
Form | Liquid |
Purification Method | Antigen affinity purification |
UNIPROT ID | Q9UI95 |
Storage Buffer | PBS Only |
Storage Conditions | Store at -80°C. |
Background Information
MAD family, together with BUB and Mps1,Cdc20k, play roles in the mitotic spindle checkpoint. MAD2L2 is one of the MAD family. It can mediate the second polymerase switching in translation DNA synthesis by mediating the interaction between the error-prone DNA polymerase zeta catalytic subunit REV3L and the inserter polymerase REV1. Through regulation of the JNK-mediate phosphorylation and activation of the transcriptional activator ELK1, MAD2L2 involves in cellular response to DNA damage. Also it has role in the progression of cell cycle and peithelial-mesenchymal transdifferentiation.