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  • KD/KO Validated

LZTS2 Polyclonal antibody

LZTS2 Polyclonal Antibody for WB, IHC, ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse

Applications

WB, IP, IF, IHC, ELISA

Conjugate

Unconjugated

Cat no : 15677-1-AP

Synonyms

hLZTS2, KIAA1813, LAPSER1, LZTS2, Protein LAPSER1



Tested Applications

Positive WB detected inHeLa cells, PC-3 cells
Positive IHC detected inhuman prostate hyperplasia tissue, human kidney tissue
Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0

Recommended dilution

ApplicationDilution
Western Blot (WB)WB : 1:1000-1:8000
Immunohistochemistry (IHC)IHC : 1:20-1:200
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

Product Information

15677-1-AP targets LZTS2 in WB, IP, IF, IHC, ELISA applications and shows reactivity with human, mouse samples.

Tested Reactivity human, mouse
Cited Reactivityhuman
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen LZTS2 fusion protein Ag8145
Full Name leucine zipper, putative tumor suppressor 2
Calculated Molecular Weight 73 kDa
Observed Molecular Weight 70-80 kDa
GenBank Accession NumberBC006212
Gene Symbol LZTS2
Gene ID (NCBI) 84445
RRIDAB_2878166
Conjugate Unconjugated
Form Liquid
Purification MethodAntigen affinity purification
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. 20ul sizes contain 0.1% BSA.

Background Information

LZTS2, also named as KIAA1813 and LAPSER1, is a novel b-Catenin-interacting protein and it regulates the nuclear export of b-Catenin. LZTS2 is a negative regulator of katanin-mediated microtubule severing and release from the centrosome. It is required for central spindle formation and the completion of cytokinesis.

Protocols

Product Specific Protocols
WB protocol for LZTS2 antibody 15677-1-APDownload protocol
IHC protocol for LZTS2 antibody 15677-1-APDownload protocol
Standard Protocols
Click here to view our Standard Protocols

Publications

SpeciesApplicationTitle
IF

Nat Commun

Proximity proteomics identifies PAK4 as a component of Afadin-Nectin junctions.

Authors - Yohendran Baskaran
humanWB,IP

Oncogene

β-Trcp and CK1δ-mediated degradation of LZTS2 activates PI3K/AKT signaling to drive tumorigenesis and metastasis in hepatocellular carcinoma.

Authors - Yanwei Lu
  • KD Validated
humanWB

Cancer Lett

LZTS2 inhibits PI3K/AKT activation and radioresistance in nasopharyngeal carcinoma by interacting with p85.

Authors - Shuangbing Xu
  • KD Validated
humanWB,IF

bioRxiv

α-catenin mechanosensitivity as a route to cytokinesis failure through sequestration of LZTS2

Authors - Yuou Wang
  • KD Validated
humanWB,IP

Cell Signal

Phosphorylation of LZTS2 by PLK1 activates the Wnt pathway

Authors - Ran Liu
humanWB

Cell Death Dis

RRP15 deficiency induces ribosome stress to inhibit colorectal cancer proliferation and metastasis via LZTS2-mediated β-catenin suppression

Authors - Zhixiong Dong