LTBP2 Polyclonal antibody

LTBP2 Polyclonal Antibody for IF, ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human and More (1)

Applications

WB, IF, IHC, ELISA

Conjugate

Unconjugated

Publications

4

Cat no : 17708-1-AP

Synonyms

C14orf141, LTBP 2, LTBP2, LTBP3, MSTP031

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Validation Data Gallery

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Published Applications

• WB: See 1 publications below
• IHC: See 4 publications below

Product Information

17708-1-AP targets LTBP2 in WB, IF, IHC, ELISA applications and shows reactivity with human samples.

• Tested Reactivity: human
• Cited Reactivity: human, mouse
• Host / Isotype: Rabbit / IgG
• Class: Polyclonal
• Type: Antibody
• Immunogen: LTBP2 fusion protein Ag12007
• Full Name: latent transforming growth factor beta binding protein 2
• Calculated Molecular Weight: 1821 aa, 195 kDa
• GenBank Accession Number: BC078659
• Gene Symbol: LTBP2
• Gene ID (NCBI): 4053
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Antigen affinity purification
• Storage Buffer: PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
• Storage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20^oC storage. 20ul sizes contain 0.1% BSA.

Background Information

LTBP2, a 240 kDa extracellular glycoprotein mapping to chromosome 14q24, belongs to a family of latent TGF-βbinding proteins (LTBPs) that regulates a well-known growth factor, TGF-β. LTBP2 is an elastic fiber-associating protein whose function in elastogenesis is not clear, as a DANCE binding Protein. It may play an integral structural role in elastic-fiber architectural organization and/or assembly. LTBP2 associates covalently with small latent TGF-beta complex via Repeat B and Repeat C. Defects in LTBP2 are the cause of primary congenital glaucoma type 3D (GLC3D). LTBP2 is a role in the structural stability of ciliary zonules, and growth and development of lens. LTBP2 null mutations in an autosomal recessive ocular syndrome with megalocornea, spherophakia, and secondary glaucoma. LTBP2 is a biomarker of heart failure.

Publications

Species	Application	Title
human	IHC	Clin Sci (Lond); LTBP2 is secreted from lung myofibroblasts and is a potential biomarker for idiopathic pulmonary fibrosis.; Authors - Yasunori Enomoto
human	IHC	Am J Transl Res; LTPB2 acts as a prognostic factor and promotes progression of cervical adenocarcinoma.; Authors - Yuan Ren
mouse	IHC	J Pain Res; PMID: 29692624; Authors - Brice Bellessort
human	WB,IHC	Biomarkers; LTBP-2 acts as a novel marker in human heart failure - a preliminary study.; Authors - Bai Yuanyuan Y