LRRTM2 Polyclonal antibody

LRRTM2 Polyclonal Antibody for WB, ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse

Applications

WB, IP, ELISA

Conjugate

Unconjugated

Publications

1

Cat no : 23094-1-AP

Synonyms

KIAA0416, LRRN2, LRRTM2

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Validation Data Gallery

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  WB analysis of mouse spinal cord using 23094-1-AP

  mouse spinal cord tissue were subjected to SDS PAGE followed by western blot with 23094-1-AP (LRRTM2 Antibody) at dilution of 1:600 incubated at room temperature for 1.5 hours.

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Tested Applications

• Positive WB detected in: mouse spinal cord tissue

Recommended dilution

• Western Blot (WB): WB : 1:500-1:1000

It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Sample-dependent, Check data in validation data gallery.

Published Applications

• IP: See 1 publications below

Product Information

The immunogen of 23094-1-AP is LRRTM2 Fusion Protein expressed in E. coli.

• Tested Reactivity: human, mouse
• Cited Reactivity: human
• Host / Isotype: Rabbit / IgG
• Class: Polyclonal
• Type: Antibody
• Immunogen: LRRTM2 fusion protein Ag19422
• Full Name: leucine rich repeat transmembrane neuronal 2
• Calculated Molecular Weight: 516 aa, 59 kDa
• Observed Molecular Weight: 59 kDa
• GenBank Accession Number: BC126408
• Gene Symbol: LRRTM2
• Gene ID (NCBI): 26045
• RRID: AB_2879209
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Antigen Affinity purified
• Storage Buffer: PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
• Storage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20^oC storage. 20ul sizes contain 0.1% BSA.

Background Information

Leucine-rich repeat transmembrane proteins (LRRTMs) are synaptic cell adhesion molecules. LRRTMs are highly localized in the postsynaptic density and play various roles in the formation, maturation, and function of synapses (PMID: 25951919). LRRTM2 acts as a post-synaptic ligand of Neurexins. LRRTM2 regulates excitatory synapse development and function in the vertebrate nervous system (PMID: 20064387).

Publications

Species	Application	Title
human	IP	Elife; The molecular appearance of native TRPM7 channel complexes identified by high-resolution proteomics; Authors - Astrid Kollewe