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LRRC2 Recombinant antibody, PBS Only

LRRC2 Uni-rAbTM Recombinant Antibody for IHC, IF/ICC, Indirect ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

IHC, IF/ICC, Indirect ELISA

Conjugate

Unconjugated

CloneNo.

241132G1

Cat no : 84404-1-PBS

Synonyms

Leucine-rich repeat-containing protein 2, 241132G1

Validation Data Gallery

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  • Immunohistochemistry (IHC) staining of mouse skeletal muscle tissue using LRRC2 Recombinant antibody (84404-1-RR)

    IHC staining of mouse skeletal muscle using 84404-1-RR (same clone as 84404-1-PBS)

    Immunohistochemical analysis of paraffin-embedded mouse skeletal muscle tissue slide using 84404-1-RR (LRRC2 antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 84404-1-PBS in a different storage buffer formulation.

  • Immunohistochemistry (IHC) staining of mouse skeletal muscle tissue using LRRC2 Recombinant antibody (84404-1-RR)

    IHC staining of mouse skeletal muscle using 84404-1-RR (same clone as 84404-1-PBS)

    Immunohistochemical analysis of paraffin-embedded mouse skeletal muscle tissue slide using 84404-1-RR (LRRC2 antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 84404-1-PBS in a different storage buffer formulation.

  • Immunofluorescence (IF) / fluorescent staining of U-251 cells using LRRC2 Recombinant antibody (84404-1-RR)

    IF Staining of U-251 using 84404-1-RR (same clone as 84404-1-PBS)

    Immunofluorescent analysis of (4% PFA) fixed U-251 cells using LRRC2 antibody (84404-1-RR, Clone: 241132G1 ) at dilution of 1:250 and CoraLite®488-Conjugated Goat Anti-Rabbit IgG(H+L) (SA00013-2), CL594-Phalloidin (red). This data was developed using the same antibody clone with 84404-1-PBS in a different storage buffer formulation.

  • Affinity and Kinetic Characterization of 84404-1-RR

    Affinity and Kinetic Characterization of 84404-1-RR

    Biolayer interferometry (BLl) kinetic assays of 84404-1-RR against Human LRRC2 were performed. The affinity constant is 26.2 nM.

Product Information

The immunogen of 84404-1-PBS is LRRC2 Fusion Protein expressed in E. coli.

Tested Reactivity human
Host / Isotype Rabbit / IgG
Class Recombinant
Type Antibody
Immunogen LRRC2 fusion protein Ag27830
Full Name leucine rich repeat containing 2
Calculated Molecular Weight 371 aa, 43 kDa
GenBank Accession NumberBC029118
Gene Symbol LRRC2
Gene ID (NCBI) 79442
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purfication
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.

Background Information

Leucine Rich Repeat Containing 2 (LRRC2) was found to be localized to the mitochondria in human cells and transcriptionally regulated by the mitochondrial master regulator Pgc-1α. It has been reported that Lrrc2 transcript abundance correlates with that of β-MHC, a canonical marker of cardiac hypertrophy in humans, and experimentally demonstrated an elevation in Lrrc2 transcript in vitro and in vivo rodent models of cardiac hypertrophy as well as in patients with dilated cardiomyopathy. (PMID: 28158196)