L3MBTL2 Polyclonal antibody

L3MBTL2 Polyclonal Antibody for WB, ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

WB, ELISA

Conjugate

Unconjugated

Cat no : 24435-1-AP

Synonyms

H l(3)mbt l, H l(3)mbt like protein 2, l(3)mbt like 2 (Drosophila), L(3)mbt like protein 2, L3MBT, L3MBTL2

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Validation Data Gallery

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  WB analysis using 24435-1-AP

  Various lysates were subjected to SDS PAGE followed by western blot with 24435-1-AP (L3MBTL2 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours.

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Tested Applications

• Positive WB detected in: U2OS cells

Recommended dilution

• Western Blot (WB): WB : 1:500-1:2000

It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Sample-dependent, Check data in validation data gallery.

Product Information

24435-1-AP targets L3MBTL2 in WB, ELISA applications and shows reactivity with human samples.

• Tested Reactivity: human
• Host / Isotype: Rabbit / IgG
• Class: Polyclonal
• Type: Antibody
• Immunogen: L3MBTL2 fusion protein Ag19571
• Full Name: l(3)mbt-like 2 (Drosophila)
• Calculated Molecular Weight: 705 aa, 79 kDa
• Observed Molecular Weight: 95-100 kDa
• GenBank Accession Number: BC017191
• Gene Symbol: L3MBTL2
• Gene ID (NCBI): 83746
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Antigen affinity purification
• Storage Buffer: PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
• Storage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20^oC storage. 20ul sizes contain 0.1% BSA.

Background Information

L3MBTL2 (Lethal (3) malignant brain tumor like 2) is a member of the MBT-domain proteins, which are involved in transcriptional repression and implicated in chromatin compaction. L3MBTL2 was most highly expressed in pachytene spermatocytes within the testis (PMID: 30760872).In addition, mutations in L3MBTL2 are prevalent in various cancers including leukemia, a disease characterized by alterations in multiple DNA repair proteins (PMID: 29581593).