CD117/c-Kit Polyclonal antibody

CD117/c-Kit Polyclonal Antibody for WB, IF, IHC, ELISA

Host / Isotype

Rabbit / IgG


human and More (4)





Cat no : 18696-1-AP


C Kit, CD117, c-Kit, c-Kit/CD117, KIT, PBT, Proto oncogene c Kit, SCFR, Tyrosine protein kinase Kit

Tested Applications

Positive WB detected inMo7e cells
Positive IHC detected instromal tumor tissue, human placenta tissue, human testis tissue, Insulinoma tissue
Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0
Positive IF detected inMCF-7 cells

Recommended dilution

Western Blot (WB)WB : 1:1000-1:4000
Immunohistochemistry (IHC)IHC : 1:50-1:500
Immunofluorescence (IF)IF : 1:50-1:500
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

Product Information

18696-1-AP targets CD117/c-Kit in WB, IF, IHC, ELISA applications and shows reactivity with human samples.

Tested Reactivity human
Cited Reactivityhuman, mouse, rat, goat, sheep
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen Peptide
Full Name v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
Calculated Molecular Weight 110 kDa
Observed Molecular Weight140-160 kDa
GenBank Accession NumberBC071593
Gene Symbol CD117
Gene ID (NCBI) 3815
Conjugate Unconjugated
Form Liquid
Purification MethodAntigen affinity purification
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. 20ul sizes contain 0.1% BSA.

Background Information

CD117, also known as c-Kit and SCFR, is a transmembrane protein with tyrosine kinase activity encoded by the oncogene c-kit (PMID: 2448137). It is a member of the type III receptor tyrosine kinase family, which also includes CSF-1R, PDGFRβ, PDGFRα, and FLT3 (PMID: 29518044). CD117 is expressed on hematopoietic stem cells and progenitor cells, mast cells, and is also found in a wide range of non-haemopoietic cell types (including melanocytes, germ cells, astrocytes, renal tubules, breast glandular epithelial cells, sweat glands, and interstitial cells of Cajal) (PMID: 10582338; 23073628). CD117 plays an important role in early hemopoiesis. It is also involved in pigmentation, fertility, gut movement, and some aspects of the nervous system (PMID: 23073628).


Product Specific Protocols
WB protocol for CD117/c-Kit antibody 18696-1-APDownload protocol
IHC protocol for CD117/c-Kit antibody 18696-1-APDownload protocol
IF protocol for CD117/c-Kit antibody 18696-1-APDownload protocol
Standard Protocols
Click here to view our Standard Protocols



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