KIR2DL1 Recombinant antibody, PBS Only

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  WB analysis using 85168-1-RR (same clone as 85168-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 85168-1-RR (KIR2DL1 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 85168-1-PBS in a different storage buffer formulation.

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  Affinity and Kinetic Characterization of 85168-1-RR

  Biolayer interferometry (BLl) kinetic assays of 85168-1-RR against Human KIR2DL1 were performed. The affinity constant is 37.9 nM.

KIR2DL1 {ptg:Brand} Recombinant Antibody for WB, Indirect ELISA

Cat No. 85168-1-PBS

Clone No.242070D11

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

WB, Indirect ELISA

Synonyms

242070D11, CD158 antigen-like family member A, CD158a, Killer cell immunoglobulin-like receptor 2DL1, Natural killer-associated transcript 1

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Product Information

85168-1-PBS targets KIR2DL1 in WB, Indirect ELISA applications and shows reactivity with human samples.

• Tested Reactivity: human
• Host / Isotype: Rabbit / IgG
• Class: Recombinant
• Type: Antibody
• Immunogen: Recombinant protein
• Full Name: killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1
• Calculated Molecular Weight: 39 kDa
• Observed Molecular Weight: 45 kDa
• GenBank Accession Number: BC069344
• Gene Symbol: KIR2DL1
• Gene ID (NCBI): 3802
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Protein A purfication
• UNIPROT ID: P43626
• Storage Buffer: PBS only , pH 7.3
• Storage Conditions: Store at -80°C.

Background Information

Killer cell immunoglobulin-like receptor 2DL1 (KIR2DL1, also known as CD158A and NKAT1) is an inhibitory receptor of NK cells, with β-arrestin 2 mediated recruitment of the tyrosine phosphatases SHP-1 and SHP-2 to KIR2DL1 and facilitated downstream inhibitory signaling (PMID: 18604210). The effector function of NK cells expressing KIR2DL1 or KIR2DS1 is highly influenced by genetic variability and is calibrated by co-expression of additional NK receptors and cognate HLA-C2 ligands (PMID: 31024561).